X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons

John L. VandeBerg, Mary Jo Aivaliotis, Paul B. Samollow

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Electrophoretic polymorphisms of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were examined in captive colonies of five subspecies of baboons (Papio hamadryas). Phenotype frequencies and family data verified the X-linked inheritance of the G6PD polymorphism. Insufficient family data were available to confirm autosomal inheritance of the 6PGD polymorphism, but the electrophoretic patterns of variant types (putative heterozygotes) suggested the codominant expression of alleles at an autosomal locus. Implications of the G6PD polymorphism are discussed with regard to its utility as a marker system for research on X-chromosome inactivation during baboon development and for studies of clonal cell proliferation and/or cell selection during the development of atherosclerotic lesions in the baboon model.

Original languageEnglish (US)
Pages (from-to)567-579
Number of pages13
JournalBiochemical Genetics
Volume30
Issue number11-12
DOIs
StatePublished - Dec 1992
Externally publishedYes

Fingerprint

Phosphogluconate Dehydrogenase
phosphogluconate dehydrogenase
Papio
Glucosephosphate Dehydrogenase
glucose-6-phosphate 1-dehydrogenase
Polymorphism
glucose
polymorphism
phosphate
genetic polymorphism
Papio hamadryas
X Chromosome Inactivation
inheritance (genetics)
X-Linked Genes
Heterozygote
Cell proliferation
X chromosome
Chromosomes
Alleles
Cell Proliferation

Keywords

  • 6-phosphogluconate dehydrogenase
  • baboon
  • glucose-6-phosphate dehydrogenase
  • Papio
  • X linkage

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics

Cite this

X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons. / VandeBerg, John L.; Aivaliotis, Mary Jo; Samollow, Paul B.

In: Biochemical Genetics, Vol. 30, No. 11-12, 12.1992, p. 567-579.

Research output: Contribution to journalArticle

VandeBerg, John L. ; Aivaliotis, Mary Jo ; Samollow, Paul B. / X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons. In: Biochemical Genetics. 1992 ; Vol. 30, No. 11-12. pp. 567-579.
@article{55e5f283bfcd431cae8a976876ebd773,
title = "X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons",
abstract = "Electrophoretic polymorphisms of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were examined in captive colonies of five subspecies of baboons (Papio hamadryas). Phenotype frequencies and family data verified the X-linked inheritance of the G6PD polymorphism. Insufficient family data were available to confirm autosomal inheritance of the 6PGD polymorphism, but the electrophoretic patterns of variant types (putative heterozygotes) suggested the codominant expression of alleles at an autosomal locus. Implications of the G6PD polymorphism are discussed with regard to its utility as a marker system for research on X-chromosome inactivation during baboon development and for studies of clonal cell proliferation and/or cell selection during the development of atherosclerotic lesions in the baboon model.",
keywords = "6-phosphogluconate dehydrogenase, baboon, glucose-6-phosphate dehydrogenase, Papio, X linkage",
author = "VandeBerg, {John L.} and Aivaliotis, {Mary Jo} and Samollow, {Paul B.}",
year = "1992",
month = "12",
doi = "10.1007/BF02399807",
language = "English (US)",
volume = "30",
pages = "567--579",
journal = "Biochemical Genetics",
issn = "0006-2928",
publisher = "Springer New York",
number = "11-12",

}

TY - JOUR

T1 - X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons

AU - VandeBerg, John L.

AU - Aivaliotis, Mary Jo

AU - Samollow, Paul B.

PY - 1992/12

Y1 - 1992/12

N2 - Electrophoretic polymorphisms of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were examined in captive colonies of five subspecies of baboons (Papio hamadryas). Phenotype frequencies and family data verified the X-linked inheritance of the G6PD polymorphism. Insufficient family data were available to confirm autosomal inheritance of the 6PGD polymorphism, but the electrophoretic patterns of variant types (putative heterozygotes) suggested the codominant expression of alleles at an autosomal locus. Implications of the G6PD polymorphism are discussed with regard to its utility as a marker system for research on X-chromosome inactivation during baboon development and for studies of clonal cell proliferation and/or cell selection during the development of atherosclerotic lesions in the baboon model.

AB - Electrophoretic polymorphisms of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were examined in captive colonies of five subspecies of baboons (Papio hamadryas). Phenotype frequencies and family data verified the X-linked inheritance of the G6PD polymorphism. Insufficient family data were available to confirm autosomal inheritance of the 6PGD polymorphism, but the electrophoretic patterns of variant types (putative heterozygotes) suggested the codominant expression of alleles at an autosomal locus. Implications of the G6PD polymorphism are discussed with regard to its utility as a marker system for research on X-chromosome inactivation during baboon development and for studies of clonal cell proliferation and/or cell selection during the development of atherosclerotic lesions in the baboon model.

KW - 6-phosphogluconate dehydrogenase

KW - baboon

KW - glucose-6-phosphate dehydrogenase

KW - Papio

KW - X linkage

UR - http://www.scopus.com/inward/record.url?scp=0027074417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027074417&partnerID=8YFLogxK

U2 - 10.1007/BF02399807

DO - 10.1007/BF02399807

M3 - Article

C2 - 1296572

AN - SCOPUS:0027074417

VL - 30

SP - 567

EP - 579

JO - Biochemical Genetics

JF - Biochemical Genetics

SN - 0006-2928

IS - 11-12

ER -