X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons

John L. VandeBerg, Mary Jo Aivaliotis, Paul B. Samollow

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    Electrophoretic polymorphisms of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were examined in captive colonies of five subspecies of baboons (Papio hamadryas). Phenotype frequencies and family data verified the X-linked inheritance of the G6PD polymorphism. Insufficient family data were available to confirm autosomal inheritance of the 6PGD polymorphism, but the electrophoretic patterns of variant types (putative heterozygotes) suggested the codominant expression of alleles at an autosomal locus. Implications of the G6PD polymorphism are discussed with regard to its utility as a marker system for research on X-chromosome inactivation during baboon development and for studies of clonal cell proliferation and/or cell selection during the development of atherosclerotic lesions in the baboon model.

    Original languageEnglish (US)
    Pages (from-to)567-579
    Number of pages13
    JournalBiochemical Genetics
    Volume30
    Issue number11
    DOIs
    StatePublished - Dec 1992

    Keywords

    • 6-phosphogluconate dehydrogenase
    • Papio
    • X linkage
    • baboon
    • glucose-6-phosphate dehydrogenase

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Biochemistry
    • Molecular Biology
    • Genetics

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