X-chromosome inactivation and evolution in marsupials and other mammals.

J. L. VandeBerg, P. G. Johnston, D. W. Cooper, E. S. Robinson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Sex chromosome dosage compensation in Australian marsupials exhibits several characteristics not ordinarily manifested in eutherian mammals. They are: 1) preferential inactivation of the paternally derived X-chromosome in somatic tissues; 2) a state of partial inactivity at some paternally derived X-linked gene loci in some cells; 3) absence of dosage compensation in some cell types; 4) absence of nuclear sex dimorphism at interphase; 5) discordance between late DNA replication and gene inactivation in some cell types; 6) failure of the X-chromosome to behave as a single unit. Despite these seemingly major differences between the dosage compensation systems of Australian marsupials and eutherians, there are also many underlying similarities. We propose that the two systems arose from a common ancestral mechanism in which the X-chromosome was regulated in a piecemeal fashion, rather than as a whole. To determine more precisely the sequence and timing of evolutionary events, we have initiated an investigation of dosage compensation in American marsupials, which diverged from Australian marsupials soon after the divergence of marsupials from eutherian mammals.

Original languageEnglish (US)
Pages (from-to)201-218
Number of pages18
JournalIsozymes
Volume9
StatePublished - 1983
Externally publishedYes

Fingerprint

Marsupialia
X Chromosome Inactivation
Mammals
X Chromosome
X-Linked Genes
Sex Chromosomes
Interphase
Gene Silencing
DNA Replication
Sex Characteristics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

VandeBerg, J. L., Johnston, P. G., Cooper, D. W., & Robinson, E. S. (1983). X-chromosome inactivation and evolution in marsupials and other mammals. Isozymes, 9, 201-218.

X-chromosome inactivation and evolution in marsupials and other mammals. / VandeBerg, J. L.; Johnston, P. G.; Cooper, D. W.; Robinson, E. S.

In: Isozymes, Vol. 9, 1983, p. 201-218.

Research output: Contribution to journalArticle

VandeBerg, JL, Johnston, PG, Cooper, DW & Robinson, ES 1983, 'X-chromosome inactivation and evolution in marsupials and other mammals.', Isozymes, vol. 9, pp. 201-218.
VandeBerg JL, Johnston PG, Cooper DW, Robinson ES. X-chromosome inactivation and evolution in marsupials and other mammals. Isozymes. 1983;9:201-218.
VandeBerg, J. L. ; Johnston, P. G. ; Cooper, D. W. ; Robinson, E. S. / X-chromosome inactivation and evolution in marsupials and other mammals. In: Isozymes. 1983 ; Vol. 9. pp. 201-218.
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