TY - JOUR
T1 - Work-up of stillbirth
T2 - a review of the evidence
AU - Silver, Robert M.
AU - Varner, Michael W.
AU - Reddy, Uma
AU - Goldenberg, Robert
AU - Pinar, Halit
AU - Conway, Deborah
AU - Bukowski, Radek
AU - Carpenter, Marshall
AU - Hogue, Carol
AU - Willinger, Marian
AU - Dudley, Donald
AU - Saade, George
AU - Stoll, Barbara
N1 - Funding Information:
This work was supported, in part, by grant funding from the Stillbirth Collaborative Research Network sites: U10-HD045953 Brown University, Rhode Island; U10-HD045925 Emory University, Georgia; U10-HD045952 University of Texas Medical Branch at Galveston, Texas; U10-HD045955 University of Texas Health Sciences Center at San Antonio, Texas; U10-HD045944 University of Utah Health Sciences Center, Utah; and U01-HD045954 RTI International, RTP.
PY - 2007/5
Y1 - 2007/5
N2 - Despite improvements in antenatal and intrapartum care, stillbirth, defined as in utero fetal death at 20 weeks of gestation or greater, remains an important, largely unstudied, and poignant problem in obstetrics. More than 26,000 stillbirths were reported in the United States in 2001. Although several conditions have been linked to stillbirth, it is difficult to define the precise etiology in many cases. This paper reviews known and suspected causes of stillbirth including genetic abnormalities, infection, fetal-maternal hemorrhage, and a variety of medical conditions in the mother. The proportion of stillbirths that have a diagnostic explanation is higher in centers that conduct a defined and systematic evaluation. The evidence for recommended diagnostic tests for stillbirth are discussed. The ongoing work of the National Institute of Child Health and Human Development Stillbirth Collaborative Research Network, a consortium of 5 academic centers in the United States that are studying the scope and causes of stillbirth, is presented.
AB - Despite improvements in antenatal and intrapartum care, stillbirth, defined as in utero fetal death at 20 weeks of gestation or greater, remains an important, largely unstudied, and poignant problem in obstetrics. More than 26,000 stillbirths were reported in the United States in 2001. Although several conditions have been linked to stillbirth, it is difficult to define the precise etiology in many cases. This paper reviews known and suspected causes of stillbirth including genetic abnormalities, infection, fetal-maternal hemorrhage, and a variety of medical conditions in the mother. The proportion of stillbirths that have a diagnostic explanation is higher in centers that conduct a defined and systematic evaluation. The evidence for recommended diagnostic tests for stillbirth are discussed. The ongoing work of the National Institute of Child Health and Human Development Stillbirth Collaborative Research Network, a consortium of 5 academic centers in the United States that are studying the scope and causes of stillbirth, is presented.
KW - etiologies
KW - stillbirth
KW - work-up
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U2 - 10.1016/j.ajog.2006.11.041
DO - 10.1016/j.ajog.2006.11.041
M3 - Review article
C2 - 17466694
AN - SCOPUS:34247209605
VL - 196
SP - 433
EP - 444
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 5
ER -