Work in progress: Transcatheter embolization with cyanoacrylate and nitrocellulose

The authors describe a modified form of isobutyl-2-cyanoacrylate (IBCA) which has been mixed with ≤ 4% w/w of nitrocellulose. Transcatheter embolization was carried out in rabbits and dogs without complications. The glue was readily injectable without balloon catheters. Because of its delayed polymerization, it was carried into smaller peripheral arterial branches by the bloodstream, resulting in complete organ ablation without development of collateral circulation. Other advantages of the modified compound include improved plasticity, adherence to not only ionic but also dry non-ionic surfaces, and the ability to control the duration of polymerization.