Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles

Shixia Huang; Katrina Podsypanina; Yidong Chen; Weiyan Cai; Anna Tsimelzon; Susan Hilsenbeck; Yi Li

doi:10.1177/153303460600500603

Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles

Shixia Huang, Katrina Podsypanina, Yidong Chen, Weiyan Cai, Anna Tsimelzon, Susan Hilsenbeck, Yi Li

Epidemiology & Biostatistics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Wnt-1 and Neu collaborate to induce mammary tumors in bitransgenic mice carrying both MMTV-Wnt-1 and MMTV-Neu. In this report, gene expression profiles were determined for tumors from these bitransgenic mice, and compared with expression profiles of tumors from mice singly transgenic for MMTV-Wnt-1 or MMTV-Neu. While very different from tumors arising in MMTV-Neu transgenic mice, tumors from these bitransgenic mice were found not to have identifiable differences from tumors from MMTV-Wnt-1 transgenic mice, using clustering and multidimensional scaling analyses (unsupervised and supervised). One-way Analysis of Variance (ANOVA), and two sample t test (the later two of which were combined with false discovery rate computation). These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles.

Original language	English (US)
Pages (from-to)	565-571
Number of pages	7
Journal	Technology in Cancer Research and Treatment
Volume	5
Issue number	6
DOIs	https://doi.org/10.1177/153303460600500603
State	Published - Dec 2006

Keywords

And Breast cancer
Gene expression profiling
Mouse model

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles",

abstract = "Wnt-1 and Neu collaborate to induce mammary tumors in bitransgenic mice carrying both MMTV-Wnt-1 and MMTV-Neu. In this report, gene expression profiles were determined for tumors from these bitransgenic mice, and compared with expression profiles of tumors from mice singly transgenic for MMTV-Wnt-1 or MMTV-Neu. While very different from tumors arising in MMTV-Neu transgenic mice, tumors from these bitransgenic mice were found not to have identifiable differences from tumors from MMTV-Wnt-1 transgenic mice, using clustering and multidimensional scaling analyses (unsupervised and supervised). One-way Analysis of Variance (ANOVA), and two sample t test (the later two of which were combined with false discovery rate computation). These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles.",

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AU - Podsypanina, Katrina

AU - Chen, Yidong

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AU - Tsimelzon, Anna

AU - Hilsenbeck, Susan

AU - Li, Yi

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