Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles

Shixia Huang, Katrina Podsypanina, Yidong Chen, Weiyan Cai, Anna Tsimelzon, Susan Hilsenbeck, Yi Li

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Wnt-1 and Neu collaborate to induce mammary tumors in bitransgenic mice carrying both MMTV-Wnt-1 and MMTV-Neu. In this report, gene expression profiles were determined for tumors from these bitransgenic mice, and compared with expression profiles of tumors from mice singly transgenic for MMTV-Wnt-1 or MMTV-Neu. While very different from tumors arising in MMTV-Neu transgenic mice, tumors from these bitransgenic mice were found not to have identifiable differences from tumors from MMTV-Wnt-1 transgenic mice, using clustering and multidimensional scaling analyses (unsupervised and supervised). One-way Analysis of Variance (ANOVA), and two sample t test (the later two of which were combined with false discovery rate computation). These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles.

Original languageEnglish (US)
Pages (from-to)565-571
Number of pages7
JournalTechnology in Cancer Research and Treatment
Volume5
Issue number6
DOIs
StatePublished - Dec 2006

Keywords

  • And Breast cancer
  • Gene expression profiling
  • Mouse model

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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