TY - JOUR
T1 - Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles
AU - Huang, Shixia
AU - Podsypanina, Katrina
AU - Chen, Yidong
AU - Cai, Weiyan
AU - Tsimelzon, Anna
AU - Hilsenbeck, Susan
AU - Li, Yi
PY - 2006/12
Y1 - 2006/12
N2 - Wnt-1 and Neu collaborate to induce mammary tumors in bitransgenic mice carrying both MMTV-Wnt-1 and MMTV-Neu. In this report, gene expression profiles were determined for tumors from these bitransgenic mice, and compared with expression profiles of tumors from mice singly transgenic for MMTV-Wnt-1 or MMTV-Neu. While very different from tumors arising in MMTV-Neu transgenic mice, tumors from these bitransgenic mice were found not to have identifiable differences from tumors from MMTV-Wnt-1 transgenic mice, using clustering and multidimensional scaling analyses (unsupervised and supervised). One-way Analysis of Variance (ANOVA), and two sample t test (the later two of which were combined with false discovery rate computation). These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles.
AB - Wnt-1 and Neu collaborate to induce mammary tumors in bitransgenic mice carrying both MMTV-Wnt-1 and MMTV-Neu. In this report, gene expression profiles were determined for tumors from these bitransgenic mice, and compared with expression profiles of tumors from mice singly transgenic for MMTV-Wnt-1 or MMTV-Neu. While very different from tumors arising in MMTV-Neu transgenic mice, tumors from these bitransgenic mice were found not to have identifiable differences from tumors from MMTV-Wnt-1 transgenic mice, using clustering and multidimensional scaling analyses (unsupervised and supervised). One-way Analysis of Variance (ANOVA), and two sample t test (the later two of which were combined with false discovery rate computation). These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles.
KW - And Breast cancer
KW - Gene expression profiling
KW - Mouse model
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U2 - 10.1177/153303460600500603
DO - 10.1177/153303460600500603
M3 - Article
C2 - 17121432
AN - SCOPUS:33846098235
VL - 5
SP - 565
EP - 571
JO - Technology in Cancer Research and Treatment
JF - Technology in Cancer Research and Treatment
SN - 1533-0346
IS - 6
ER -