Wilms' tumor

A paradigm for the new genetics

Karim Malik, Pearlly Yan, Hui-ming Huang, Keith W. Brown

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Carcinogenesis can be triggered by a diverse range of molecular lesions, a variety of which can be illustrated by Wilms' tumor (WT), a pediatric kidney cancer. Molecular defects observed in WTs include several independent targets and mechanisms best exemplified by changes on the short arm of chromosome 11. This article will review the molecular pathology of WT and emphasize the broader ramifications for cancer genetics. Consideration will be given to carcinogenic pathways, novel cellular molecules, and technologies that will assist in the rapid interpretation and assimilation of DNA sequence data arising from the sequencing of the human genome.

Original languageEnglish (US)
Pages (from-to)441-449
Number of pages9
JournalOncology Research
Volume12
Issue number11-12
StatePublished - 2000
Externally publishedYes

Fingerprint

Wilms Tumor
Chromosomes, Human, Pair 11
Molecular Pathology
Kidney Neoplasms
Human Genome
Carcinogenesis
Pediatrics
Technology
Neoplasms

Keywords

  • Epigenetics
  • Genomics
  • Tumor suppressor genes
  • Wilms' tumor
  • WT1

ASJC Scopus subject areas

  • Cancer Research

Cite this

Malik, K., Yan, P., Huang, H., & Brown, K. W. (2000). Wilms' tumor: A paradigm for the new genetics. Oncology Research, 12(11-12), 441-449.

Wilms' tumor : A paradigm for the new genetics. / Malik, Karim; Yan, Pearlly; Huang, Hui-ming; Brown, Keith W.

In: Oncology Research, Vol. 12, No. 11-12, 2000, p. 441-449.

Research output: Contribution to journalArticle

Malik, K, Yan, P, Huang, H & Brown, KW 2000, 'Wilms' tumor: A paradigm for the new genetics', Oncology Research, vol. 12, no. 11-12, pp. 441-449.
Malik K, Yan P, Huang H, Brown KW. Wilms' tumor: A paradigm for the new genetics. Oncology Research. 2000;12(11-12):441-449.
Malik, Karim ; Yan, Pearlly ; Huang, Hui-ming ; Brown, Keith W. / Wilms' tumor : A paradigm for the new genetics. In: Oncology Research. 2000 ; Vol. 12, No. 11-12. pp. 441-449.
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