Abstract
Introduction: Prior to the introduction of sentinel lymph node sampling, wide excision and axillary dissectionfollowed by radiation to the breast was considered a standard treatment for breast cancer. Not all patients who undergobreast conserving surgery receive radiation therapy, which is considered suboptimal care. We have evaluated ourexperience with wide excision alone and its effect on local-regional recurrence, development of metastatic disease andsurvival.Materials and Methods: Between 1987-1997 we identified 69 patients (70 breasts) treated with wide excision withoutradiation for their primary breast cancer.Results: The median age at diagnosis was 79 years. Median follow-up was 6.7 years. The median tumor size was 1.1 cm(range 0.2 - 3.5 cm). Fifty three percent of the patients received tamoxifen. Tumor size was significant for failure andsurvival. Seven (10%) patients failed. Only 6 patients (9%) had an ipsilateral recurrence requiring surgical intervention.Two of the six developed metastatic disease. One additional patient had distant spread without a detected local failure.Overall, 3 (4%) developed metastatic disease and died with breast cancer as a contributing factor. Sixty four percent of thepatients died without contribution from the breast cancer, and 31% were alive without disease.Conclusions: Not all patients require radiation for cancer control after wide excision. Patients who can be considered forsurgery alone without an unacceptable risk are the elderly (especially those with comorbid conditions with small lowgrade tumors treated with wide surgical margins).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 13-17 |
| Number of pages | 5 |
| Journal | Open Breast Cancer Journal |
| Volume | 3 |
| DOIs | |
| State | Published - 2011 |
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Keywords
- Breast cancer
- Breast conservation.fiojfpmdfk
- Lumpectomy alone
- Wide excision
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Wide excision without radiation as primary treatment for breast cancerin older patients. / Swanson, Gregory P; Lagow, Elaine; Riggs, Mark; Symmonds, Richard.
In: Open Breast Cancer Journal, Vol. 3, 2011, p. 13-17.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Wide excision without radiation as primary treatment for breast cancerin older patients
AU - Swanson, Gregory P
AU - Lagow, Elaine
AU - Riggs, Mark
AU - Symmonds, Richard
PY - 2011
Y1 - 2011
N2 - Introduction: Prior to the introduction of sentinel lymph node sampling, wide excision and axillary dissectionfollowed by radiation to the breast was considered a standard treatment for breast cancer. Not all patients who undergobreast conserving surgery receive radiation therapy, which is considered suboptimal care. We have evaluated ourexperience with wide excision alone and its effect on local-regional recurrence, development of metastatic disease andsurvival.Materials and Methods: Between 1987-1997 we identified 69 patients (70 breasts) treated with wide excision withoutradiation for their primary breast cancer.Results: The median age at diagnosis was 79 years. Median follow-up was 6.7 years. The median tumor size was 1.1 cm(range 0.2 - 3.5 cm). Fifty three percent of the patients received tamoxifen. Tumor size was significant for failure andsurvival. Seven (10%) patients failed. Only 6 patients (9%) had an ipsilateral recurrence requiring surgical intervention.Two of the six developed metastatic disease. One additional patient had distant spread without a detected local failure.Overall, 3 (4%) developed metastatic disease and died with breast cancer as a contributing factor. Sixty four percent of thepatients died without contribution from the breast cancer, and 31% were alive without disease.Conclusions: Not all patients require radiation for cancer control after wide excision. Patients who can be considered forsurgery alone without an unacceptable risk are the elderly (especially those with comorbid conditions with small lowgrade tumors treated with wide surgical margins).
AB - Introduction: Prior to the introduction of sentinel lymph node sampling, wide excision and axillary dissectionfollowed by radiation to the breast was considered a standard treatment for breast cancer. Not all patients who undergobreast conserving surgery receive radiation therapy, which is considered suboptimal care. We have evaluated ourexperience with wide excision alone and its effect on local-regional recurrence, development of metastatic disease andsurvival.Materials and Methods: Between 1987-1997 we identified 69 patients (70 breasts) treated with wide excision withoutradiation for their primary breast cancer.Results: The median age at diagnosis was 79 years. Median follow-up was 6.7 years. The median tumor size was 1.1 cm(range 0.2 - 3.5 cm). Fifty three percent of the patients received tamoxifen. Tumor size was significant for failure andsurvival. Seven (10%) patients failed. Only 6 patients (9%) had an ipsilateral recurrence requiring surgical intervention.Two of the six developed metastatic disease. One additional patient had distant spread without a detected local failure.Overall, 3 (4%) developed metastatic disease and died with breast cancer as a contributing factor. Sixty four percent of thepatients died without contribution from the breast cancer, and 31% were alive without disease.Conclusions: Not all patients require radiation for cancer control after wide excision. Patients who can be considered forsurgery alone without an unacceptable risk are the elderly (especially those with comorbid conditions with small lowgrade tumors treated with wide surgical margins).
KW - Breast cancer
KW - Breast conservation.fiojfpmdfk
KW - Lumpectomy alone
KW - Wide excision
UR - http://www.scopus.com/inward/record.url?scp=79959946668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959946668&partnerID=8YFLogxK
U2 - 10.2174/1876817201103010013
DO - 10.2174/1876817201103010013
M3 - Article
AN - SCOPUS:79959946668
VL - 3
SP - 13
EP - 17
JO - Open Breast Cancer Journal
JF - Open Breast Cancer Journal
SN - 1876-8172
ER -