Why primate models matter

Kimberley A. Phillips, Karen L. Bales, John P. Capitanio, Alan Conley, Paul W. Czoty, Bert A. 't Hart, William D. Hopkins, Shiu Lok Hu, Lisa A. Miller, Michael A. Nader, Peter W. Nathanielsz, Jeffrey Rogers, Carol A. Shively, Mary Lou Voytko

Research output: Contribution to journalReview article

204 Scopus citations

Abstract

Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their similarity to humans in physiology, neuroanatomy, reproduction, development, cognition, and social complexity-yet it is these very similarities that make the use of NHPs in biomedical research a considered decision. As primate researchers, we feel an obligation and responsibility to present the facts concerning why primates are used in various areas of biomedical research. Recent decisions in the United States, including the phasing out of chimpanzees in research by the National Institutes of Health and the pending closure of the New England Primate Research Center, illustrate to us the critical importance of conveying why continued research with primates is needed. Here, we review key areas in biomedicine where primate models have been, and continue to be, essential for advancing fundamental knowledge in biomedical and biological research. Am. J. Primatol. 76:801-827, 2014.

Original languageEnglish (US)
Pages (from-to)801-827
Number of pages27
JournalAmerican Journal of Primatology
Volume76
Issue number9
DOIs
StatePublished - Sep 2014

Keywords

  • Animal models
  • Nonhuman primates
  • Translational research

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Animal Science and Zoology

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    Phillips, K. A., Bales, K. L., Capitanio, J. P., Conley, A., Czoty, P. W., 't Hart, B. A., Hopkins, W. D., Hu, S. L., Miller, L. A., Nader, M. A., Nathanielsz, P. W., Rogers, J., Shively, C. A., & Voytko, M. L. (2014). Why primate models matter. American Journal of Primatology, 76(9), 801-827. https://doi.org/10.1002/ajp.22281