Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease

A. González-Pérez; J. Gayán; J. Marín; J. J. Galán; M. E. Sáez; L. M. Real; C. Antúnez; A. Ruiz

doi:10.1007/s10048-009-0170-8

Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease

A. González-Pérez, J. Gayán, J. Marín, J. J. Galán, M. E. Sáez, L. M. Real, C. Antúnez, A. Ruiz

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Whole-genome epistasis analysis may add a new layer of knowledge to whole-genome association studies, permitting the identification of new candidate genes which are completely transparent during conventional single-locus analysis. We present the first whole-genome conditional two-locus analysis in Parkinson's disease (PD). We scanned the entire genome and selected markers that interacted with a set of well-known loci previously associated to PD (SNCA, Parkin, LRRK2, UCHL1, DJ-1, PINK and MAPT). Our work describes several loci potentially related to PD risk which interact with SNCA, PARK1 and LRRK2 markers. We propose conditional whole-genome two-locus association analysis as a valuable method that might be helpful in re-analysing and re-interpreting data from whole-genome association studies.

Original language	English (US)
Pages (from-to)	173-181
Number of pages	9
Journal	Neurogenetics
Volume	10
Issue number	3
DOIs	https://doi.org/10.1007/s10048-009-0170-8
State	Published - Jul 2009
Externally published	Yes

Keywords

Genetic epistasis
Interaction
Parkinson's disease
Single nucleotide polymorphism
Whole-genome association study

ASJC Scopus subject areas

Genetics
Genetics(clinical)
Cellular and Molecular Neuroscience

Access to Document

10.1007/s10048-009-0170-8

Cite this

@article{1ca49cd65cec489499d53b32ffbc5f38,

title = "Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease",

abstract = "Whole-genome epistasis analysis may add a new layer of knowledge to whole-genome association studies, permitting the identification of new candidate genes which are completely transparent during conventional single-locus analysis. We present the first whole-genome conditional two-locus analysis in Parkinson's disease (PD). We scanned the entire genome and selected markers that interacted with a set of well-known loci previously associated to PD (SNCA, Parkin, LRRK2, UCHL1, DJ-1, PINK and MAPT). Our work describes several loci potentially related to PD risk which interact with SNCA, PARK1 and LRRK2 markers. We propose conditional whole-genome two-locus association analysis as a valuable method that might be helpful in re-analysing and re-interpreting data from whole-genome association studies.",

keywords = "Genetic epistasis, Interaction, Parkinson's disease, Single nucleotide polymorphism, Whole-genome association study",

author = "A. Gonz{\'a}lez-P{\'e}rez and J. Gay{\'a}n and J. Mar{\'i}n and Gal{\'a}n, {J. J.} and S{\'a}ez, {M. E.} and Real, {L. M.} and C. Ant{\'u}nez and A. Ruiz",

year = "2009",

month = jul,

doi = "10.1007/s10048-009-0170-8",

language = "English (US)",

volume = "10",

pages = "173--181",

journal = "Neurogenetics",

issn = "1364-6745",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "3",

}

TY - JOUR

T1 - Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease

AU - González-Pérez, A.

AU - Gayán, J.

AU - Marín, J.

AU - Galán, J. J.

AU - Sáez, M. E.

AU - Real, L. M.

AU - Antúnez, C.

AU - Ruiz, A.

PY - 2009/7

Y1 - 2009/7

N2 - Whole-genome epistasis analysis may add a new layer of knowledge to whole-genome association studies, permitting the identification of new candidate genes which are completely transparent during conventional single-locus analysis. We present the first whole-genome conditional two-locus analysis in Parkinson's disease (PD). We scanned the entire genome and selected markers that interacted with a set of well-known loci previously associated to PD (SNCA, Parkin, LRRK2, UCHL1, DJ-1, PINK and MAPT). Our work describes several loci potentially related to PD risk which interact with SNCA, PARK1 and LRRK2 markers. We propose conditional whole-genome two-locus association analysis as a valuable method that might be helpful in re-analysing and re-interpreting data from whole-genome association studies.

AB - Whole-genome epistasis analysis may add a new layer of knowledge to whole-genome association studies, permitting the identification of new candidate genes which are completely transparent during conventional single-locus analysis. We present the first whole-genome conditional two-locus analysis in Parkinson's disease (PD). We scanned the entire genome and selected markers that interacted with a set of well-known loci previously associated to PD (SNCA, Parkin, LRRK2, UCHL1, DJ-1, PINK and MAPT). Our work describes several loci potentially related to PD risk which interact with SNCA, PARK1 and LRRK2 markers. We propose conditional whole-genome two-locus association analysis as a valuable method that might be helpful in re-analysing and re-interpreting data from whole-genome association studies.

KW - Genetic epistasis

KW - Interaction

KW - Parkinson's disease

KW - Single nucleotide polymorphism

KW - Whole-genome association study

UR - http://www.scopus.com/inward/record.url?scp=70249126212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70249126212&partnerID=8YFLogxK

U2 - 10.1007/s10048-009-0170-8

DO - 10.1007/s10048-009-0170-8

M3 - Article

C2 - 19156451

AN - SCOPUS:70249126212

SN - 1364-6745

VL - 10

SP - 173

EP - 181

JO - Neurogenetics

JF - Neurogenetics

IS - 3

ER -

Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this