Whole blood transfusion reduces overall component transfusion in cases of placenta accreta spectrum: a pilot program

Jessian L. Munoz, Alison M. Kimura, Elly M Xenakis, Donald H. Jenkins, Maxwell A. Braverman, Patrick S. Ramsey, Kayla E. Ireland

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Placenta accreta spectrum (PAS) is a group of placental invasion pathologies associated with significant morbidity to both mother and fetus. The majority of patients with PAS will require a blood transfusion at time of delivery and subsequent cesarean hysterectomy. The optimal approach to maternal acute blood loss resuscitation is currently unknown. Methods: Here, we present a cohort analysis of 34 patients with pathology-confirmed PAS treated with either whole blood (n = 16) or component therapy (n = 18) for initial intraoperative resuscitation. Results: We observed comparable results in post-operative outcomes with fewer overall transfusions and subsequently, lower volumes of resuscitation (p=.03) with whole blood initial resuscitation. Conclusions: Whole blood transfusion may represent a viable option for initial resuscitation with lower resuscitation volumes and transfusion-associated complications without directly effecting post-operative outcomes in cases of PAS.

Original languageEnglish (US)
JournalJournal of Maternal-Fetal and Neonatal Medicine
DOIs
StateAccepted/In press - 2021

Keywords

  • abnormal placentation
  • blood transfusion
  • cesarean hysterectomy
  • Placenta accreta
  • whole blood

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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