Whole blood platelet aggregation in normal pregnancy and pre-eclampsia

B. Splawinska, A. Skret, R. Palczak, J. Janeczko, W. Furmaga, J. Splawinski

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Platelet aggregation in whole blood in response to ADP, plasma beta-thromboglobulin (beta-TG) and thromboxane B2 (TXB2) levels, were evaluated in third-trimester patients with pre-eclanipsia (PE) (n==15) and in healthy third-trimester pregnant controls (n==43). 1 min after blood collection there was no difference in platelet response to ADP between PE and controls. Storage of blood unmasked hypoaggregability of platelets in PE implicating contribution of labile pro-aggregatory substance to ADP-induced aggregation tested at I min. Plasma TXB2 in 10 controls (39.4 ± 8.7 pg/ml) was lower (p<0.05) than in 4 PE subjects (212.8 ± 130.0 pg/ml). Thus, seemingly normal aggregation of platelets to ADP in PE at I min after blood collection may be attributed to increased plasma level of TXA2. Increased plasma level of beta-TG in PE (49.2 ± 7.0 ng/ml vs 27.3 ± 3.0 ng/ml; p<0.01) appears to be secondary to platelet consumption in which circulating TXA2 may play a role.

Original languageEnglish (US)
Pages (from-to)311-319
Number of pages9
JournalHypertension in Pregnancy
VolumeB6
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • Platelet aggregation
  • Pre-eclampsia
  • Whole blood

ASJC Scopus subject areas

  • Internal Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Whole blood platelet aggregation in normal pregnancy and pre-eclampsia'. Together they form a unique fingerprint.

Cite this