Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study

Joel Salinas, Honghuang Lin, Hugo J. Aparico, Tianxiao Huan, Chunyu Liu, Jian Rong, Alexa Beiser, Jayandra J. Himali, Jane E. Freedman, Martin G. Larson, Jonathan Rosand, Hermona Soreq, Daniel Levy, Sudha Seshadri

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Emerging evidence suggests microRNAs (miRNAs) may play an important role in explaining variation in stroke risk and recovery in humans, yet there are still few longitudinal studies examining the association between whole blood miRNAs and stroke. Accounting for multiple testing and adjusting for potentially confounding technical and clinical variables, here we show that whole blood miR-574-3p expression was significantly lower in participants with chronic stroke compared to non-cases. To explore the functional relevance of our findings, we analyzed miRNA-mRNA whole blood co-expression, pathway enrichment, and brain tissue gene expression. Results suggest miR-574-3p is involved in neurometabolic and chronic neuronal injury response pathways, including brain gene expression of DBNDD2 and ELOVL1. These results suggest miR-574-3p plays a role in regulating chronic brain and systemic cellular response to stroke and thus may implicate miR-574-3p as a partial mediator of long-term stroke outcomes.

Original languageEnglish (US)
Article numbere0219261
JournalPloS one
Volume14
Issue number8
DOIs
StatePublished - Aug 1 2019
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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