When the Circadian Clock Meets the Melanin Pigmentary System

Andrzej T. Slominski, Rüdiger Hardeland, Russel J. Reiter

Research output: Contribution to journalComment/debate

7 Scopus citations

Abstract

Silencing of BMAL1 and PER1 stimulates melanogenic activity of follicular and epidermal melanocytes, indicating a novel role for peripheral circadian clock processes in the regulation of melanin pigmentation. Linking the expression levels of BMAL1PER1 with changes in melanogenesis opens exciting opportunities to study the role of the local molecular clock in modulation of melanocyte functions in the hair follicle and the epidermis with attendant effects on epidermal barrier functions in general.

Original languageEnglish (US)
Pages (from-to)943-945
Number of pages3
JournalJournal of Investigative Dermatology
Volume135
Issue number4
DOIs
StatePublished - Apr 20 2015

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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