When the Circadian Clock Meets the Melanin Pigmentary System

Andrzej T. Slominski; Rüdiger Hardeland; Russel J. Reiter

doi:10.1038/jid.2014.553

When the Circadian Clock Meets the Melanin Pigmentary System

Andrzej T. Slominski, Rüdiger Hardeland, Russel J. Reiter

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Comment/debate › peer-review

16 Scopus citations

Abstract

Silencing of BMAL1 and PER1 stimulates melanogenic activity of follicular and epidermal melanocytes, indicating a novel role for peripheral circadian clock processes in the regulation of melanin pigmentation. Linking the expression levels of BMAL1PER1 with changes in melanogenesis opens exciting opportunities to study the role of the local molecular clock in modulation of melanocyte functions in the hair follicle and the epidermis with attendant effects on epidermal barrier functions in general.

Original language	English (US)
Pages (from-to)	943-945
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	135
Issue number	4
DOIs	https://doi.org/10.1038/jid.2014.553
State	Published - Apr 20 2015

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1038/jid.2014.553

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abstract = "Silencing of BMAL1 and PER1 stimulates melanogenic activity of follicular and epidermal melanocytes, indicating a novel role for peripheral circadian clock processes in the regulation of melanin pigmentation. Linking the expression levels of BMAL1PER1 with changes in melanogenesis opens exciting opportunities to study the role of the local molecular clock in modulation of melanocyte functions in the hair follicle and the epidermis with attendant effects on epidermal barrier functions in general.",

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AU - Reiter, Russel J.

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AB - Silencing of BMAL1 and PER1 stimulates melanogenic activity of follicular and epidermal melanocytes, indicating a novel role for peripheral circadian clock processes in the regulation of melanin pigmentation. Linking the expression levels of BMAL1PER1 with changes in melanogenesis opens exciting opportunities to study the role of the local molecular clock in modulation of melanocyte functions in the hair follicle and the epidermis with attendant effects on epidermal barrier functions in general.

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When the Circadian Clock Meets the Melanin Pigmentary System

Abstract

ASJC Scopus subject areas

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