Wheat germ agglutinin liposomes with surface grafted cyclodextrins as bioadhesive dual-drug delivery nanocarriers to treat oral cells

Sashini S. Wijetunge, Jianchuan Wen, Chih Ko Yeh, Yuyu Sun

Research output: Contribution to journalArticle

Abstract

Topical management of oral infection requires combined use of multiple classes of drugs and frequent dosing due to low drug retention rates. The sustained, co-delivery of drugs with different solubilities to cells using nanoparticle drug delivery systems remains a challenge. Here, we developed wheat germ agglutinin (WGA) conjugated liposomes with surface grafted cyclodextrin (WGA-liposome-CD) as bioadhesive dual-drug nanocarriers. We effectively encapsulated two physiochemically different drugs (ciprofloxacin and betamethasone) and demonstrated sustained co-drug release in saliva over a 24 h period in vitro. As proof of therapeutic utility in oral cells, we infected oral keratinocytes with Aggregatibacter actinomycetemcomitans, a bacterial pathogen responsible for chronic periodontal disease. Drug release, resulting from nanocarrier cell binding, produced a significant increase in oral cell survival and synergistically reduced inflammation. These results suggest that WGA-liposome-CD nanocarriers are novel cyto-adhesive candidates for delivering multiple drugs with sustained therapeutic activity for localized drug delivery to oral cells.

Original languageEnglish (US)
Article number110572
JournalColloids and Surfaces B: Biointerfaces
Volume185
DOIs
StatePublished - Jan 1 2020

Fingerprint

Wheat Germ Agglutinins
wheat
Liposomes
Cyclodextrins
Drug delivery
delivery
drugs
cells
Pharmaceutical Preparations
Pathogens
Adhesives
Solubility
Cells
Nanoparticles
Aggregatibacter actinomycetemcomitans
Betamethasone
Periodontal Diseases
Drug Delivery Systems
Ciprofloxacin
Keratinocytes

Keywords

  • Cyclodextrin
  • Drug delivery
  • Dual-drug encapsulation
  • Liposome
  • Wheat germ agglutinin

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Wheat germ agglutinin liposomes with surface grafted cyclodextrins as bioadhesive dual-drug delivery nanocarriers to treat oral cells. / Wijetunge, Sashini S.; Wen, Jianchuan; Yeh, Chih Ko; Sun, Yuyu.

In: Colloids and Surfaces B: Biointerfaces, Vol. 185, 110572, 01.01.2020.

Research output: Contribution to journalArticle

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