What are RBC-transfusion-dependence and -independence?

R. P. Gale, G. Barosi, T. Barbui, F. Cervantes, K. Dohner, B. Dupriez, V. Gupta, C. Harrison, R. Hoffman, J. J. Kiladjian, R. Mesa, M. F. Mc Mullin, F. Passamonti, V. Ribrag, G. Roboz, G. Saglio, A. Vannucchi, S. Verstovsek

Research output: Contribution to journalLetterpeer-review

55 Scopus citations

Abstract

The term RBC-transfusion-dependence is widely-used by hematologists to describe a condition of severe anemia typically arising when erythropoiesis is reduced such that a person continuously requires ≥1 RBC-transfusions over a specified interval. Defining a person as RBC-transfusion-dependent has important implications in diverse hematological disorders especially because it strongly-correlated with decreased survival. Conversely, becoming RBC-transfusion-independent or receiving fewer RBC-transfusions over a specified interval is defined as improvement or response in many disease- and/or therapy-setting. Whether this correlates with improved survival is controversial. We used a structured expert-panel consensus panel process to define RBC-transfusion-dependence and -independence or improvement. We suggest these definitions may prove useful to persons studying or treating these diseases.

Original languageEnglish (US)
Pages (from-to)8-11
Number of pages4
JournalLeukemia Research
Volume35
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

Keywords

  • Anemia
  • Anemia therapy
  • Aplastic anemia
  • Myelodysplastic syndrome
  • Myeloproliferative neoplasm
  • Paroxysmal nocturnal hemoglobinuria
  • RBC-transfusions

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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