Weekly vinorelbine versus docetaxel for metastatic breast cancer after failing anthracycline treatment

Carl Richard Meier, Hans Jochen Illiger, Martin Steder, Jan Janssen, Holger Deertz, Manfred Braun, Hueseyin Taylan Oeney, Burkhard Deuss, Thomas Küchler, Susanne Rotermund

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Vinorelbine and docetaxel are active in anthracycline- pretreated, metastatic breast cancer. We compared their efficacy. Patients and Methods: Patients were randomized to receive weekly vinorelbine (VIN) or weekly docetaxel (DOC), 6 weekly doses per 8-week cycle, with optional crossover (X-DOC vs. X-VIN. The primary end point was time to progression (TTP) on initial treatment. Remission induction, survival, and quality of life were secondary end points. Results: Among 122 poor risk patients, a non-significant trend for better TTP was seen for DOC, both on initial and on crossover treatment. Responses were seen on either treatment, but progression was more common with VIN than with DOC, while more patients had a response with X-DOC than with X-VIN. Survival was identical in those receiving only the initial VIN vs. DOC and in the subgroups receiving crossover treatments. Grade 3-4 toxicity, especially hematological toxicity resulting in treatment delay, was more common with VIN. Non-graded toxicity contributed to abandoning DOC. Quality of life scores reflected worse results in patients crossing treatment arms, in either direction. Conclusions: DOC showed marginally better activity but did not improve TTP or other endpoints over VIN in this poor risk population.

Original languageEnglish (US)
Pages (from-to)447-453
Number of pages7
JournalOnkologie
Volume31
Issue number8-9
DOIs
StatePublished - Sep 2008

Keywords

  • Crossover studies
  • Docetaxel
  • Metastatic breast cancer
  • Quality of life
  • Vinorelbine

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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