Weak direct current accelerates split-thickness graft healing on tangentially excised second-degree burns

Chi Sing Chu, Albert T. McManus, Carlin V. Okerberg, Arthur D. Mason, Basil A. Pruitt

Research output: Contribution to journalArticle

18 Scopus citations


We have examined the effects of direct current (DC) conducted through silver-nylon dressings on the healing time and morphologic maturation of split-thickness grafts placed on tangentially excised deep partial-thickness burn wounds. Male guinea pigs (n = 120) were used as the experimental hosts. The DC-treated animals required 2 days for complete revascularization of their grafts; control animals required 7 days (p < 0.01). The DC-treated animals had increased epithelial proliferation at the graft-wound interface as compared with controls (p < 0.01). Grafts from DC-treated animals were firmly adherent within 4 days, whereas graft adherence in controls was weak before 7 days after grafting. At 3 months after grafting, control animal grafts had mild contraction with moderate hair loss and thick subepidermal fibrosis; the grafts in DC-treated animals expanded with the growth of the animals and had abundant hair growdi and significantly reduced dermal fibrosis (p < 0.01).

Original languageEnglish (US)
Pages (from-to)285-293
Number of pages9
JournalJournal of Burn Care and Rehabilitation
Issue number4
StatePublished - Jan 1 1991


ASJC Scopus subject areas

  • Surgery
  • Nursing(all)
  • Emergency Medicine
  • Rehabilitation
  • Health Professions(all)

Cite this