Was the historic contribution of spain to the mexican gene pool partially responsible for the higher prevalence of type 2 diabetes in mexican-origin populations?

Carlos Lorenzo, Manel Serrano-Rios, Maria T. Martinez-Larrad, Rafael Gabriel, Ken Williams, Clicerio Gonzalez-Villalpando, Michel P. Stern, Helen P. Hazuda, Steven M. Haffner

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

OBJECTIVE - Mexican-American populations in San Antonio, Texas (SA-MA) and Mexico have a higher prevalence of type 2 diabetes than non-Hispanic whites in San Antonio (SA-NHW). However, the higher prevalence of type 2 diabetes in Mexican-origin populations might be related, in part, not to Native American genetic admixture but to Spanish genetic admixture. RESEARCH DESIGN AND METHODS - Four population-based epidemiological surveys conducted with Mexican-origin and European-origin samples provided data relevant to this question. In all four surveys, type 2 diabetes was defined as fasting plasma glucose ≥7.0 mmol/l or 2-h glucose ≥ 11.1 mmol/l or use of antidiabetic agents. RESULTS - A comparison of the two Mexican-origin populations showed that the age- and sex-adjusted prevalence of type 2 diabetes was lower in Mexico than in SA-MA (15.1 vs. 17.9%, P = 0.032). Between the two European-origin populations, the prevalence of type 2 diabetes was lower in SA-NHW than in Spain (6.2 vs. 9.1%, P < 0.0001), but differences were attenuated by adjustment for BMI or after stratification by education. In logistic regression analyses, type 2 diabetes was associated with Mexican ethnic origin after adjusting for age, education, BMI, and waist-to-hip ratio. CONCLUSIONS - The prevalence of type 2 diabetes in Spain was intermediate between that in Mexican-origin populations and SA-NHW. Although the higher degree of Native American admixture is a major contributor to the higher rates of type 2 diabetes, we cannot completely rule out a partial contribution of Spanish admixture to diabetes susceptibility among Mexicanorigin populations.

Original languageEnglish (US)
Pages (from-to)2059-2064
Number of pages6
JournalDiabetes care
Volume24
Issue number12
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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    Lorenzo, C., Serrano-Rios, M., Martinez-Larrad, M. T., Gabriel, R., Williams, K., Gonzalez-Villalpando, C., Stern, M. P., Hazuda, H. P., & Haffner, S. M. (2001). Was the historic contribution of spain to the mexican gene pool partially responsible for the higher prevalence of type 2 diabetes in mexican-origin populations? Diabetes care, 24(12), 2059-2064. https://doi.org/10.2337/diacare.24.12.2059