Walking speed as an aging biomarker in baboons (Papio hamadryas)

Hillary F. Huber; Kenneth G. Gerow; Peter W. Nathanielsz

doi:10.1111/jmp.12199

Walking speed as an aging biomarker in baboons (Papio hamadryas)

Hillary F. Huber, Kenneth G. Gerow, Peter W. Nathanielsz

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Walking speed is an important human aging biomarker. Baboons are valuable translational models for aging studies. Establishing whether walking speed is a good aging biomarker has value. We hypothesized there would be characteristic age-related decline in baboon walking speed. Methods: We studied 33 female baboons aged 5-21 years. Walking speed was calculated by the time to walk between landmarks separated by known distances. A regression model was developed to describe the relationship between speed, age, and body weight. Results: Speed negatively associated with age, a relationship enhanced by increased weight (P < 0.0005). For 16-kg animals, speed declined approximately 0.6 cm/s yearly. For each additional kilogram of weight, speed declined an additional 0.3 cm/s yearly. Conclusions: Baboon walking speed declines with age, an effect modulated by weight. Ease of measurement and strong age association make walking speed a valuable biomarker for aging research with this important experimental species.

Original language	English (US)
Pages (from-to)	373-380
Number of pages	8
Journal	Journal of medical primatology
Volume	44
Issue number	6
DOIs	https://doi.org/10.1111/jmp.12199
State	Published - Dec 1 2015
Externally published	Yes

Keywords

Age-related decline
Gait speed
Non-human primates
Physical mobility

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1111/jmp.12199

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title = "Walking speed as an aging biomarker in baboons (Papio hamadryas)",

abstract = "Background: Walking speed is an important human aging biomarker. Baboons are valuable translational models for aging studies. Establishing whether walking speed is a good aging biomarker has value. We hypothesized there would be characteristic age-related decline in baboon walking speed. Methods: We studied 33 female baboons aged 5-21 years. Walking speed was calculated by the time to walk between landmarks separated by known distances. A regression model was developed to describe the relationship between speed, age, and body weight. Results: Speed negatively associated with age, a relationship enhanced by increased weight (P < 0.0005). For 16-kg animals, speed declined approximately 0.6 cm/s yearly. For each additional kilogram of weight, speed declined an additional 0.3 cm/s yearly. Conclusions: Baboon walking speed declines with age, an effect modulated by weight. Ease of measurement and strong age association make walking speed a valuable biomarker for aging research with this important experimental species.",

keywords = "Age-related decline, Gait speed, Non-human primates, Physical mobility",

author = "Huber, {Hillary F.} and Gerow, {Kenneth G.} and Nathanielsz, {Peter W.}",

note = "Funding Information: This work was supported by funding from the FP7 Health Programme of the EU, 5R24 RR021367 (Nutrient Restriction and Developmental Programming), and R21HD057480 (Effects of Prenatal Nutrition on Developmental Outcomes in the Juvenile Baboon). Special thanks are due to Steve Rios for his support in study preparation and animal handling. We also thank Martha Avila and Sam Vega for their skilled maintenance of the animals, and Sue Jenkins for data archiving and analysis. Publisher Copyright: {\textcopyright} 2015 John Wiley & Sons A/S.",

year = "2015",

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doi = "10.1111/jmp.12199",

language = "English (US)",

volume = "44",

pages = "373--380",

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T1 - Walking speed as an aging biomarker in baboons (Papio hamadryas)

AU - Huber, Hillary F.

AU - Gerow, Kenneth G.

AU - Nathanielsz, Peter W.

N1 - Funding Information: This work was supported by funding from the FP7 Health Programme of the EU, 5R24 RR021367 (Nutrient Restriction and Developmental Programming), and R21HD057480 (Effects of Prenatal Nutrition on Developmental Outcomes in the Juvenile Baboon). Special thanks are due to Steve Rios for his support in study preparation and animal handling. We also thank Martha Avila and Sam Vega for their skilled maintenance of the animals, and Sue Jenkins for data archiving and analysis. Publisher Copyright: © 2015 John Wiley & Sons A/S.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background: Walking speed is an important human aging biomarker. Baboons are valuable translational models for aging studies. Establishing whether walking speed is a good aging biomarker has value. We hypothesized there would be characteristic age-related decline in baboon walking speed. Methods: We studied 33 female baboons aged 5-21 years. Walking speed was calculated by the time to walk between landmarks separated by known distances. A regression model was developed to describe the relationship between speed, age, and body weight. Results: Speed negatively associated with age, a relationship enhanced by increased weight (P < 0.0005). For 16-kg animals, speed declined approximately 0.6 cm/s yearly. For each additional kilogram of weight, speed declined an additional 0.3 cm/s yearly. Conclusions: Baboon walking speed declines with age, an effect modulated by weight. Ease of measurement and strong age association make walking speed a valuable biomarker for aging research with this important experimental species.

AB - Background: Walking speed is an important human aging biomarker. Baboons are valuable translational models for aging studies. Establishing whether walking speed is a good aging biomarker has value. We hypothesized there would be characteristic age-related decline in baboon walking speed. Methods: We studied 33 female baboons aged 5-21 years. Walking speed was calculated by the time to walk between landmarks separated by known distances. A regression model was developed to describe the relationship between speed, age, and body weight. Results: Speed negatively associated with age, a relationship enhanced by increased weight (P < 0.0005). For 16-kg animals, speed declined approximately 0.6 cm/s yearly. For each additional kilogram of weight, speed declined an additional 0.3 cm/s yearly. Conclusions: Baboon walking speed declines with age, an effect modulated by weight. Ease of measurement and strong age association make walking speed a valuable biomarker for aging research with this important experimental species.

KW - Age-related decline

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KW - Non-human primates

KW - Physical mobility

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Walking speed as an aging biomarker in baboons (Papio hamadryas)

Abstract

Keywords

ASJC Scopus subject areas

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