Waist circumference is genetically correlated with incident Type 2 diabetes in Mexican-American families

M. Mamtani, H. Kulkarni, T. D. Dyer, L. Almasy, M. C. Mahaney, R. Duggirala, A. G. Comuzzie, J. Blangero, J. E. Curran

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Aims: We aimed to determine the genetic and environmental correlation between various anthropometric indexes and incident Type 2 diabetes with a focus on waist circumference. Methods: We used the data on extended Mexican-American families (808 subjects, 7617.92 person-years follow-up) from the San Antonio Family Heart Study and estimated the genetic and environmental correlations of 16 anthropometric indexes with the genetic liability of incident Type 2 diabetes. We performed bivariate trait analyses using the solar software package. Results: All 16 anthropometric indexes were significantly heritable (range of heritabilities 0.24-0.99). Thirteen indexes were found to have significant environmental correlation with the liability of incident Type 2 diabetes. In contrast, only anthropometric indexes consisting of waist circumference (waist circumference, waist-hip ratio and waist-height ratio) were significantly genetically correlated (genetic correlation coefficients: 0.45, 0.55 and 0.44, respectively) with the liability of incident Type 2 diabetes. We did not observe such a correlation for BMI. Conclusions: Waist circumference as a predictor of future Type 2 diabetes is supported by the finding that they share common genetic influences.

Original languageEnglish (US)
Pages (from-to)31-35
Number of pages5
JournalDiabetic Medicine
Volume31
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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