The low-molecular peptide fractions are obtained from the brain of experimental and control animals by the method which includes sedimentation of high-molecular compounds and gel-filtration on Sephadex G-10. Ischemia of the rat brain sharply changes the amino acidic composition of the isolated peptide fractions. An inhibitory effect of the studied fractions on the activity of DNA-dependent RNA polymerase as well as their effect on the heat denaturation of exogenous DNA are established.
|Translated title of the contribution||Isolation and characteristics of peptide fractions from the rat brain in ischemia|
|Number of pages||5|
|Journal||Ukrainski¿ biokhimicheski¿ zhurnal|
|State||Published - Nov 1985|
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