TY - JOUR
T1 - Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availability
AU - Antonow-Schlorke, Iwa
AU - Schwab, Matthias
AU - Cox, Laura A.
AU - Li, Cun
AU - Stuchlik, Kristina
AU - Witte, Otto W.
AU - Nathanielsz, Peter W.
AU - McDonald, Thomas J.
PY - 2011/2/15
Y1 - 2011/2/15
N2 - Moderate maternal nutrient restriction during pregnancy occurs in both developing and developed countries. In addition to poverty, maternal dieting, teenage pregnancy, and uterine vascular problems in older mothers are causes of decreased fetal nutrition. We evaluated the impact of global 30% maternal nutrient reduction (MNR) on early fetal baboon brain maturation. MNR induced major cerebral developmental disturbances without fetal growth restriction or marked maternal weight reduction. Mechanisms evaluated included neurotrophic factor suppression, cell proliferation and cell death imbalance, impaired glial maturation and neuronal process formation, down-regulation of gene ontological pathways and related gene products, and up-regulated transcription of cerebral catabolism. Contrary to the known benefits from this degree of dietary reduction on life span, MNR in pregnancy compromises structural fetal cerebral development, potentially having an impact on brain function throughout life.
AB - Moderate maternal nutrient restriction during pregnancy occurs in both developing and developed countries. In addition to poverty, maternal dieting, teenage pregnancy, and uterine vascular problems in older mothers are causes of decreased fetal nutrition. We evaluated the impact of global 30% maternal nutrient reduction (MNR) on early fetal baboon brain maturation. MNR induced major cerebral developmental disturbances without fetal growth restriction or marked maternal weight reduction. Mechanisms evaluated included neurotrophic factor suppression, cell proliferation and cell death imbalance, impaired glial maturation and neuronal process formation, down-regulation of gene ontological pathways and related gene products, and up-regulated transcription of cerebral catabolism. Contrary to the known benefits from this degree of dietary reduction on life span, MNR in pregnancy compromises structural fetal cerebral development, potentially having an impact on brain function throughout life.
KW - Brain development
KW - Environment
KW - Epigenetics
KW - Fetus
KW - Malnutrition
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U2 - 10.1073/pnas.1009838108
DO - 10.1073/pnas.1009838108
M3 - Article
C2 - 21252306
AN - SCOPUS:79952586789
SN - 0027-8424
VL - 108
SP - 3011
EP - 3016
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 7
ER -