VT-1161 protects immunosuppressed mice from Rhizopus arrhizus var. arrhizus infection

Teclegiorgis Gebremariam; Nathan P. Wiederhold; Annette W. Fothergill; Edward P. Garvey; William J. Hoekstra; Robert J. Schotzinger; Thomas F. Patterson; Scott G. Filler; Ashraf S. Ibrahim

doi:10.1128/AAC.01437-15

VT-1161 protects immunosuppressed mice from Rhizopus arrhizus var. arrhizus infection

Teclegiorgis Gebremariam
, Nathan P. Wiederhold
, Annette W. Fothergill
, Edward P. Garvey
, William J. Hoekstra
, Robert J. Schotzinger
, Thomas F. Patterson
, Scott G. Filler
, Ashraf S. Ibrahim

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

We studied the efficacy of the investigational drug VT-1161 against mucormycosis. VT-1161 had more potent in vitro activity against Rhizopus arrhizus var. arrhizus than against R. arrhizus var. delemar. VT-1161 treatment demonstrated dose-dependent plasma drug levels with prolonged survival time and lowered tissue fungal burden in immunosuppressed mice infected with R. arrhizus var. arrhizus and was as effective as high-dose liposomal amphotericin B treatment. These results support further development of VT-1161 against mucormycosis.

Original language	English (US)
Pages (from-to)	7815-7817
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	59
Issue number	12
DOIs	https://doi.org/10.1128/AAC.01437-15
State	Published - Dec 1 2015

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "VT-1161 protects immunosuppressed mice from Rhizopus arrhizus var. arrhizus infection",

abstract = "We studied the efficacy of the investigational drug VT-1161 against mucormycosis. VT-1161 had more potent in vitro activity against Rhizopus arrhizus var. arrhizus than against R. arrhizus var. delemar. VT-1161 treatment demonstrated dose-dependent plasma drug levels with prolonged survival time and lowered tissue fungal burden in immunosuppressed mice infected with R. arrhizus var. arrhizus and was as effective as high-dose liposomal amphotericin B treatment. These results support further development of VT-1161 against mucormycosis.",

author = "Teclegiorgis Gebremariam and Wiederhold, \{Nathan P.\} and Fothergill, \{Annette W.\} and Garvey, \{Edward P.\} and Hoekstra, \{William J.\} and Schotzinger, \{Robert J.\} and Patterson, \{Thomas F.\} and Filler, \{Scott G.\} and Ibrahim, \{Ashraf S.\}",

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doi = "10.1128/AAC.01437-15",

language = "English (US)",

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T1 - VT-1161 protects immunosuppressed mice from Rhizopus arrhizus var. arrhizus infection

AU - Gebremariam, Teclegiorgis

AU - Wiederhold, Nathan P.

AU - Fothergill, Annette W.

AU - Garvey, Edward P.

AU - Hoekstra, William J.

AU - Schotzinger, Robert J.

AU - Patterson, Thomas F.

AU - Filler, Scott G.

AU - Ibrahim, Ashraf S.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - We studied the efficacy of the investigational drug VT-1161 against mucormycosis. VT-1161 had more potent in vitro activity against Rhizopus arrhizus var. arrhizus than against R. arrhizus var. delemar. VT-1161 treatment demonstrated dose-dependent plasma drug levels with prolonged survival time and lowered tissue fungal burden in immunosuppressed mice infected with R. arrhizus var. arrhizus and was as effective as high-dose liposomal amphotericin B treatment. These results support further development of VT-1161 against mucormycosis.

AB - We studied the efficacy of the investigational drug VT-1161 against mucormycosis. VT-1161 had more potent in vitro activity against Rhizopus arrhizus var. arrhizus than against R. arrhizus var. delemar. VT-1161 treatment demonstrated dose-dependent plasma drug levels with prolonged survival time and lowered tissue fungal burden in immunosuppressed mice infected with R. arrhizus var. arrhizus and was as effective as high-dose liposomal amphotericin B treatment. These results support further development of VT-1161 against mucormycosis.

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AN - SCOPUS:84954496267

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IS - 12

ER -

VT-1161 protects immunosuppressed mice from Rhizopus arrhizus var. arrhizus infection

Abstract

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