Vβ-specific immunotoxin selectively kills acetylcholine receptor-reactive T lymphocytes from mice with experimental autoimmune myasthenia gravis

Patricia A. Thompson, Robert Mcatee, Anthony J. Infante, Patricia Currier, William Beninatl, Keith A. Krolick

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Immunization of C57BL/6 mice with purified acetytchollne receptor (AChR) is known to induce a T cell-dependent antibody response that results in experimental autoimmune myasthenia gravis (EAMG). Since past observations link Vβ6+ T cells with a prominent AChR epitope specificity, a Vβ6-specific immunotoxin (VIT6) was tested in vitro for its ability to selectively kill monoclonal and polyclonal T cells that demonstrate reactivity against AChR. Results described below clearly demonstrate the ability to selectively kill AChR-reactlve T cells based on their expression of a particular Vβ-associated antigen receptor.

Original languageEnglish (US)
Pages (from-to)1807-1815
Number of pages9
JournalInternational Immunology
Volume6
Issue number12
DOIs
StatePublished - Dec 1 1994

Keywords

  • Autoimmune disease
  • T cell receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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