Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder

Manpreet K. Singh, Kiki D. Chang, Michael C. Chen, Ryan G. Kelley, Amy S Garrett, Myles M. Mitsunaga, Layla Bararpour, Meghan Howe, Allan L. Reiss, Ian H. Gotlib

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objectives: A range of prefrontal and subcortical volumetric abnormalities have been found in adults and adolescents with bipolar disorder. It is unclear, however, if these deficits are present early in the onset of mania or are a consequence of multiple mood episodes or prolonged exposure to medication. The goal of this study was to examine whether youth with bipolar I disorder who recently experienced their first episode of mania are characterized by brain volumetric abnormalities. Methods: Anatomical images from magnetic resonance imaging of 26 13- to 18-year-old adolescents with bipolar I disorder and 24 age-comparable healthy controls with no personal or family history of psychopathology were analyzed using whole-brain voxel-based morphometry (VBM). Results: Compared with healthy controls, adolescents with bipolar I disorder had significantly less gray matter volume in the left subgenual cingulate cortex [p<0.05, family-wise error (FWE)-corrected]. Conclusions: Adolescents with a recent single episode of mania have smaller subgenual cingulate cortex volume than do their healthy counterparts, suggesting that this anomaly occurs early in the onset of, or may predate the disorder. Longitudinal studies are needed to examine the impact of this volumetric reduction on the course and outcome of this disorder.

Original languageEnglish (US)
Pages (from-to)585-596
Number of pages12
JournalBipolar Disorders
Volume14
Issue number6
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

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Gyrus Cinguli
Bipolar Disorder
Brain
Prednisolone
Psychopathology
Longitudinal Studies
Magnetic Resonance Imaging

Keywords

  • Adolescent
  • Bipolar disorder
  • First episode mania
  • Lithium
  • Subgenual anterior cingulate cortex
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder. / Singh, Manpreet K.; Chang, Kiki D.; Chen, Michael C.; Kelley, Ryan G.; Garrett, Amy S; Mitsunaga, Myles M.; Bararpour, Layla; Howe, Meghan; Reiss, Allan L.; Gotlib, Ian H.

In: Bipolar Disorders, Vol. 14, No. 6, 01.09.2012, p. 585-596.

Research output: Contribution to journalArticle

Singh, MK, Chang, KD, Chen, MC, Kelley, RG, Garrett, AS, Mitsunaga, MM, Bararpour, L, Howe, M, Reiss, AL & Gotlib, IH 2012, 'Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder', Bipolar Disorders, vol. 14, no. 6, pp. 585-596. https://doi.org/10.1111/j.1399-5618.2012.01043.x
Singh, Manpreet K. ; Chang, Kiki D. ; Chen, Michael C. ; Kelley, Ryan G. ; Garrett, Amy S ; Mitsunaga, Myles M. ; Bararpour, Layla ; Howe, Meghan ; Reiss, Allan L. ; Gotlib, Ian H. / Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder. In: Bipolar Disorders. 2012 ; Vol. 14, No. 6. pp. 585-596.
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