Volumetric MRI Differences in Treatment Naïve and Chronically Treated Adolescents With ADHD-Combined Type

Margaret Semrud-Clikeman; Steven R. Pliszka; Jesse Bledsoe; Jack Lancaster

doi:10.1177/1087054712443158

Volumetric MRI Differences in Treatment Naïve and Chronically Treated Adolescents With ADHD-Combined Type

Margaret Semrud-Clikeman, Steven R. Pliszka, Jesse Bledsoe, Jack Lancaster

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Objective: The purpose of this study was to determine whether there are differences in the volume of specific brain regions using magnetic resonance imaging (MRI) between children and adolescents with ADHD and controls and whether such differences are related to the participants' history of stimulant treatment. Method: A total of 16 healthy controls, 16 children, and adolescents with ADHD-combined (ADHD-C) type with a history of stimulant treatment, and 13 children and adolescents with ADHD-C type treatment naïve participated. Results: Total frontal, prefrontal, and caudate volumes were larger for children and adolescents with ADHD compared with controls with no differences based on medication history with larger right gray and white matter prefrontal volumes in the ADHD groups. A medication difference was found with the right anterior cingulate cortex smaller in children and adolescents without a treatment history. Conclusion: These findings suggest that aberrant prefrontal and caudate volumes in ADHD-C may compromise functioning of the frontostriatal circuitry.

Original language	English (US)
Pages (from-to)	511-520
Number of pages	10
Journal	Journal of Attention Disorders
Volume	18
Issue number	6
DOIs	https://doi.org/10.1177/1087054712443158
State	Published - Aug 2014

Keywords

ADHD
adolescents
imaging
medication

ASJC Scopus subject areas

Clinical Psychology
Developmental and Educational Psychology

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10.1177/1087054712443158

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title = "Volumetric MRI Differences in Treatment Na{\"i}ve and Chronically Treated Adolescents With ADHD-Combined Type",

abstract = "Objective: The purpose of this study was to determine whether there are differences in the volume of specific brain regions using magnetic resonance imaging (MRI) between children and adolescents with ADHD and controls and whether such differences are related to the participants' history of stimulant treatment. Method: A total of 16 healthy controls, 16 children, and adolescents with ADHD-combined (ADHD-C) type with a history of stimulant treatment, and 13 children and adolescents with ADHD-C type treatment na{\"i}ve participated. Results: Total frontal, prefrontal, and caudate volumes were larger for children and adolescents with ADHD compared with controls with no differences based on medication history with larger right gray and white matter prefrontal volumes in the ADHD groups. A medication difference was found with the right anterior cingulate cortex smaller in children and adolescents without a treatment history. Conclusion: These findings suggest that aberrant prefrontal and caudate volumes in ADHD-C may compromise functioning of the frontostriatal circuitry.",

keywords = "ADHD, adolescents, imaging, medication",

author = "Margaret Semrud-Clikeman and Pliszka, {Steven R.} and Jesse Bledsoe and Jack Lancaster",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The National Institute of Mental Health Grant R01 MH63986 funded this study.",

year = "2014",

month = aug,

doi = "10.1177/1087054712443158",

language = "English (US)",

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T1 - Volumetric MRI Differences in Treatment Naïve and Chronically Treated Adolescents With ADHD-Combined Type

AU - Semrud-Clikeman, Margaret

AU - Pliszka, Steven R.

AU - Bledsoe, Jesse

AU - Lancaster, Jack

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The National Institute of Mental Health Grant R01 MH63986 funded this study.

PY - 2014/8

Y1 - 2014/8

N2 - Objective: The purpose of this study was to determine whether there are differences in the volume of specific brain regions using magnetic resonance imaging (MRI) between children and adolescents with ADHD and controls and whether such differences are related to the participants' history of stimulant treatment. Method: A total of 16 healthy controls, 16 children, and adolescents with ADHD-combined (ADHD-C) type with a history of stimulant treatment, and 13 children and adolescents with ADHD-C type treatment naïve participated. Results: Total frontal, prefrontal, and caudate volumes were larger for children and adolescents with ADHD compared with controls with no differences based on medication history with larger right gray and white matter prefrontal volumes in the ADHD groups. A medication difference was found with the right anterior cingulate cortex smaller in children and adolescents without a treatment history. Conclusion: These findings suggest that aberrant prefrontal and caudate volumes in ADHD-C may compromise functioning of the frontostriatal circuitry.

AB - Objective: The purpose of this study was to determine whether there are differences in the volume of specific brain regions using magnetic resonance imaging (MRI) between children and adolescents with ADHD and controls and whether such differences are related to the participants' history of stimulant treatment. Method: A total of 16 healthy controls, 16 children, and adolescents with ADHD-combined (ADHD-C) type with a history of stimulant treatment, and 13 children and adolescents with ADHD-C type treatment naïve participated. Results: Total frontal, prefrontal, and caudate volumes were larger for children and adolescents with ADHD compared with controls with no differences based on medication history with larger right gray and white matter prefrontal volumes in the ADHD groups. A medication difference was found with the right anterior cingulate cortex smaller in children and adolescents without a treatment history. Conclusion: These findings suggest that aberrant prefrontal and caudate volumes in ADHD-C may compromise functioning of the frontostriatal circuitry.

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KW - adolescents

KW - imaging

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Volumetric MRI Differences in Treatment Naïve and Chronically Treated Adolescents With ADHD-Combined Type

Abstract

Keywords

ASJC Scopus subject areas

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