Volume control of plasma antidiuretic hormone concentration following acute blood volume expansion in the anesthetized dog

R. E. Shade, L. Share

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Acute volume expansion was produced in 9 dogs by infusing a lactated Ringer's solution at 1 ml/kg/min in a volume estimated to increase blood volume by 20%. Volume expansion was maintained by replacing urinary fluid losses with equal volumes of the Ringer's solution. Following volume expansion, the effects of a slow, nonhypotensive hemorrhage on plasma antidiuretic hormone concentration (P(ADH)) were determined and compared to a group of 9 normovolemic dogs subjected to the same hemorrhage procedure, in order to determine if volume receptor control of ADH release would adapt to acute increases in blood volume. Ringer's infusion significantly increased blood volume to 95.2 ± 3.1 ml/kg (mean ± SE; P<0.01) when compared to a mean normovolemic blood volume of 77.6 ± 3.4 ml/kg. Volume expansion was associated with a significantly lower P(ADH) (3.2 ± 1.6 μU/ml) than that in normovolemic dogs (5.7 ± 1.2 μU/ml; p<0.05). Significant increases in P(ADH)(P<0.05) occurred in both groups of dogs after 20 and 40 min of a continuous, nonhypotensive hemorrhage (0.40 to 0.45 mg/kg/min). Hemorrhage was also associated with significant decreases in effective left atrial pressure in both groups of dogs after 5, 10, 20, and 40 min of hemorrhage (P<0.01). There were no significant differences between the two groups of dogs nor were there any significant changes during the experiment within each group for mean arterial blood pressure, arterial pulse pressure, plasma osmolality, plasma sodium concentration and plasma potassium concentration. Effective left atrial pressure and P(ADH) were found to be exponentially correlated with blood volume in both hypervolemic and normovolemic dogs. Analysis of covariance of these correlations suggested that the hypervolemic dogs exhibited the same exponential changes in P(ADH) and effective left atrial pressure with decreased blood volume as in the normovolemic dogs. It is concluded that acute volume expansion does not alter volume control of plasma ADH concentration.

Original languageEnglish (US)
Pages (from-to)1048-1057
Number of pages10
JournalEndocrinology
Volume97
Issue number4
StatePublished - 1975
Externally publishedYes

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Plasma Volume
Blood Volume
Vasopressins
Dogs
Atrial Pressure
Hemorrhage
Arterial Pressure
Osmolar Concentration
Potassium
Sodium
Blood Pressure

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Volume control of plasma antidiuretic hormone concentration following acute blood volume expansion in the anesthetized dog. / Shade, R. E.; Share, L.

In: Endocrinology, Vol. 97, No. 4, 1975, p. 1048-1057.

Research output: Contribution to journalArticle

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abstract = "Acute volume expansion was produced in 9 dogs by infusing a lactated Ringer's solution at 1 ml/kg/min in a volume estimated to increase blood volume by 20{\%}. Volume expansion was maintained by replacing urinary fluid losses with equal volumes of the Ringer's solution. Following volume expansion, the effects of a slow, nonhypotensive hemorrhage on plasma antidiuretic hormone concentration (P(ADH)) were determined and compared to a group of 9 normovolemic dogs subjected to the same hemorrhage procedure, in order to determine if volume receptor control of ADH release would adapt to acute increases in blood volume. Ringer's infusion significantly increased blood volume to 95.2 ± 3.1 ml/kg (mean ± SE; P<0.01) when compared to a mean normovolemic blood volume of 77.6 ± 3.4 ml/kg. Volume expansion was associated with a significantly lower P(ADH) (3.2 ± 1.6 μU/ml) than that in normovolemic dogs (5.7 ± 1.2 μU/ml; p<0.05). Significant increases in P(ADH)(P<0.05) occurred in both groups of dogs after 20 and 40 min of a continuous, nonhypotensive hemorrhage (0.40 to 0.45 mg/kg/min). Hemorrhage was also associated with significant decreases in effective left atrial pressure in both groups of dogs after 5, 10, 20, and 40 min of hemorrhage (P<0.01). There were no significant differences between the two groups of dogs nor were there any significant changes during the experiment within each group for mean arterial blood pressure, arterial pulse pressure, plasma osmolality, plasma sodium concentration and plasma potassium concentration. Effective left atrial pressure and P(ADH) were found to be exponentially correlated with blood volume in both hypervolemic and normovolemic dogs. Analysis of covariance of these correlations suggested that the hypervolemic dogs exhibited the same exponential changes in P(ADH) and effective left atrial pressure with decreased blood volume as in the normovolemic dogs. It is concluded that acute volume expansion does not alter volume control of plasma ADH concentration.",
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