Vitreous and aqueous penetration of orally administered trimethoprim-sulfamethoxazole combination in humans

Vahid Feiz, Lisa Nijm, Randolph D. Glickman, Lawrence S. Morse, David G. Telander, Susanna S. Park, Christopher R. Polage, Steven M. Christiansen, Majid Moshirfar

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Purpose: To determine the penetration of orally administered trimethoprim (TMP)-sulfamethoxazole (SMX) into the aqueous and vitreous cavity of noninflamed human eyes. Methods: Nine adult patients undergoing cataract surgery and 10 adult patients undergoing pars plana vitrectomy were given 3 doses of oral TMP-SMX every 12 hours before the surgery. Aqueous and blood samples were collected from patients undergoing cataract surgery; vitreous and blood samples were collected from patients undergoing vitrectomy. The levels of TMP and SMX were analyzed using high-performance liquid chromatography and were compared with the mean minimum inhibitory concentrations (MIC90) of potential ocular pathogens. Results: TMP-SMX was present in all samples. Among eyes undergoing cataract surgery, the mean concentrations of TMP in aqueous and blood were 0.341 ± 0.141 μg/mL (mean ± SD) and 1.501 ± 0.433 μg/mL and of SMX were 5.259 ± 0.929 μg/mL and 11.835 ± 2.100 μg/mL, respectively. Among eyes undergoing vitrectomy, the mean concentrations of TMP in vitreous and blood were 1.864 ± 0.807 μg/mL and 4.591 ± 2.979 μg/mL and of SMX were 5.910 ± 2.705 μg/mL and 39.289 ± 15.469 μg/mL, respectively. MIC90 levels were achieved against many bacterial pathogens, including methicillin-resistant Staphylococcus aureus. Conclusions: TMP-SMX penetrates both the aqueous and vitreous cavities when given orally. The components reach therapeutic inhibitory concentrations in the ocular cavity against many potential pathogens. Copyrigt

Original languageEnglish (US)
Pages (from-to)1315-1320
Number of pages6
JournalCornea
Volume32
Issue number10
DOIs
StatePublished - Oct 1 2013

Keywords

  • Aqueous
  • Bactrim
  • Endophthalmitis
  • Sulfamethoxazole
  • Trimethoprim
  • Vitrectomy
  • Vitreous

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Vitreous and aqueous penetration of orally administered trimethoprim-sulfamethoxazole combination in humans'. Together they form a unique fingerprint.

  • Cite this

    Feiz, V., Nijm, L., Glickman, R. D., Morse, L. S., Telander, D. G., Park, S. S., Polage, C. R., Christiansen, S. M., & Moshirfar, M. (2013). Vitreous and aqueous penetration of orally administered trimethoprim-sulfamethoxazole combination in humans. Cornea, 32(10), 1315-1320. https://doi.org/10.1097/ICO.0b013e318298ddf8