Vitamin E supplement use and the incidence of cardiovascular disease and all-cause mortality in the Framingham Heart Study: Does the underlying health status play a role?

M. Dietrich, P. F. Jacques, M. J. Pencina, K. Lanier, M. J. Keyes, G. Kaur, P. A. Wolf, R. B. D'Agostino, R. S. Vasan

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Background: Observational studies generally showed beneficial associations between supplemental vitamin E intake and cardiovascular disease (CVD) risk whereas intervention trials reported adverse effects of vitamin E supplements. We hypothesize that these discordant findings result from differing underlying health status of study participants in observational and intervention studies. Objective: Determine if the relation between supplemental vitamin E intake and CVD and all-cause mortality (ACM) depends on pre-existing CVD. Design: Proportional hazards regression to relate supplemental vitamin E intake to the 10-year incidence of CVD and ACM in 4270 Framingham Study participants stratified by baseline CVD status. Results: Eleven percent of participants used vitamin E supplements at baseline. In participants with pre-existing CVD, there were 28 (44%) and 20 (32%) incident cases of CVD and ACM in the vitamin E supplement users versus 249 (47%) and 202 (38%) in the non-users, respectively (CVD HR, 0.90; 95% CL, 0.60-1.32; ACM HR, 0.74; 95% CL, 0.46-1.17). In participants without pre-existing CVD, there were 51 (13%) and 47 (12%) cases of CVD and ACM in the vitamin E supplement group versus 428 (13%) and 342 (10%) in the non-vitamin E supplement group, respectively (CVD HR, 1.00; 95% CL, 0.75-1.34; ACM HR 1.20; 95% CL, 0.89-1.64). Conclusion: CVD status has no apparent influence on the association of supplemental vitamin E intake and risk for CVD and ACM in this large, community-based study. Further research is needed to clarify the basis for the discrepant results between intervention and observational studies of supplemental vitamin E intake.

Original languageEnglish (US)
Pages (from-to)549-553
Number of pages5
JournalAtherosclerosis
Volume205
Issue number2
DOIs
StatePublished - Aug 2009
Externally publishedYes

Keywords

  • All-cause mortality
  • Cardiovascular disease
  • Framingham Heart Study
  • Health status
  • Vitamin E supplements

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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