Vitamin D concentration and lateral cerebral ventricle volume in older adults

Cédric Annweiler, Manuel Montero-Odasso, Vladimir Hachinski, Sudha Seshadri, Robert Bartha, Olivier Beauchet

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Scope: Vitamin D deficiency is associated with an enlargement of the lateral cerebral ventricles in rodents. The effect of low serum 25-hydroxyvitamin D (25OHD) on lateral cerebral ventricle volume has not been studied yet in humans. The purpose of this cross-sectional study was to determine whether vitamin D deficiency was associated with greater lateral cerebral ventricle volume in older adults. Methods and results: Ninety-two Caucasian community-dwellers with no clinical hydrocephalus (mean, 72.2 ± 6.2 years; 46.7% female) were divided into two groups according to serum 25OHD concentration (deficiency ≤ 50 nmol/L; normal > 50 nmol/L). Cerebral ventricular volume was quantified using semi-automated software from three-dimensional T1-weighted MRI. Age, gender, body mass index, blood pressure, education level, Mini-Mental State Examination, white matter lesions, and serum calcium concentrations were used as covariates. There was an inverse linear association between 25OHD concentration and ventricular volume (p = 0.049). Compared to individuals with normal 25OHD, those with 25OHD deficiency (n = 33) had 28% larger lateral ventricles (46.9 ± 26.8 mL versus 36.6 ± 16.4 mL, p = 0.026). Vitamin D deficiency was associated with an increase in ventricular volume (adjustedβ = 16.55, p = 0.023). The ventricular enlargement involved ventricle bodies (p = 0.025) but not temporal horns (p = 0.112). Conclusion: Serum 25OHD deficiency was associated with larger lateral cerebral ventricles. These findings provide a scientific base for vitamin D replacement trials.

Original languageEnglish (US)
Pages (from-to)267-276
Number of pages10
JournalMolecular Nutrition and Food Research
Issue number2
StatePublished - Feb 2013
Externally publishedYes


  • Lateral cerebral ventricle
  • Neurodegeneration
  • Neuroendocrinology
  • Older adults
  • Vitamin D

ASJC Scopus subject areas

  • Biotechnology
  • Food Science


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