Vitamin D and cartilage

Barbara D. Boyan, Maryam Doroudi, Anjali Verma, Zvi Schwartz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Two metabolites of vitamin D3, 1a,25-dihydroxyvitamin D3 (1α,25(OH)2D3) and 24R,25-dihydroxyvitamin D3 (24R,25(OH)2D3) regulate growth plate physiology. The effects of each metabolite are limited to different subsets of cells in specific zones of the growth plate; different mechanisms of action are used by the metabolites to exert their effects in their target cells. In resting zone chondrocytes, 24R,25(OH)2D3 maintains the pool of resting zone chondrocytes and protects against apoptosis; in growth zone chondrocytes, 1α,25(OH)2D3 stimulates differentiation, maturation, and cartilage calcification. Together these metabolites cycle to maintain growth plate homeostasis.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Pages592-598
Number of pages7
ISBN (Electronic)9780128093245
DOIs
StatePublished - Jan 1 2016

Keywords

  • 1α,25(OH)D
  • 24R,25(OH)D
  • Articular cartilage
  • Cartilage
  • Chondrocyte
  • Cyp24A1
  • Cyp27B1
  • Growth plate
  • Growth zone
  • Pdia3
  • Resting zone
  • VDR
  • Vitamin D

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Vitamin D and cartilage'. Together they form a unique fingerprint.

  • Cite this

    Boyan, B. D., Doroudi, M., Verma, A., & Schwartz, Z. (2016). Vitamin D and cartilage. In The Curated Reference Collection in Neuroscience and Biobehavioral Psychology (pp. 592-598). Elsevier Science Ltd.. https://doi.org/10.1016/B978-0-12-809324-5.03233-8