Visualization of experimental glioma C6 by MRI with magnetic nanoparticles conjugated with monoclonal antibodies to vascular endothelial growth factor

M. A. Abakumov; S. A. Shein; H. Vishvasrao; N. V. Nukolova; M. Sokol'Ski-Papkov; T. O. Sandalova; I. L. Gubskii; N. F. Grinenko; A. V. Kabanov; V. P. Chekhonin

doi:10.1007/s10517-012-1929-8

Visualization of experimental glioma C6 by MRI with magnetic nanoparticles conjugated with monoclonal antibodies to vascular endothelial growth factor

M. A. Abakumov, S. A. Shein, H. Vishvasrao, N. V. Nukolova, M. Sokol'Ski-Papkov, T. O. Sandalova, I. L. Gubskii, N. F. Grinenko, A. V. Kabanov, V. P. Chekhonin

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We developed a method for obtaining iron oxide nanoparticles and their conjugation with monoclonal antibodies to vascular endothelial growth factor. The resultant vector nanoparticles were low-toxic and the antibodies retained their immunochemical activity after conjugation. The study was carried out on rats with intracranial glioma C6 on day 14 after its implantation. The intravenously injected nanoparticles visualized the brain tumor in contrast to nanoparticles conjugated with nonspecific immunoglobulins that did not accumulate in the tumor.

Original language	English (US)
Pages (from-to)	274-277
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	154
Issue number	2
DOIs	https://doi.org/10.1007/s10517-012-1929-8
State	Published - Dec 2012
Externally published	Yes

Keywords

MRI
magnetic nanoparticles
vascular endothelial growth factor

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/s10517-012-1929-8

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Abakumov, M. A., Shein, S. A., Vishvasrao, H., Nukolova, N. V., Sokol'Ski-Papkov, M., Sandalova, T. O., Gubskii, I. L., Grinenko, N. F., Kabanov, A. V., & Chekhonin, V. P. (2012). Visualization of experimental glioma C6 by MRI with magnetic nanoparticles conjugated with monoclonal antibodies to vascular endothelial growth factor. Bulletin of Experimental Biology and Medicine, 154(2), 274-277. https://doi.org/10.1007/s10517-012-1929-8

Abakumov, MA, Shein, SA, Vishvasrao, H, Nukolova, NV, Sokol'Ski-Papkov, M, Sandalova, TO, Gubskii, IL, Grinenko, NF, Kabanov, AV & Chekhonin, VP 2012, 'Visualization of experimental glioma C6 by MRI with magnetic nanoparticles conjugated with monoclonal antibodies to vascular endothelial growth factor', Bulletin of Experimental Biology and Medicine, vol. 154, no. 2, pp. 274-277. https://doi.org/10.1007/s10517-012-1929-8

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title = "Visualization of experimental glioma C6 by MRI with magnetic nanoparticles conjugated with monoclonal antibodies to vascular endothelial growth factor",

abstract = "We developed a method for obtaining iron oxide nanoparticles and their conjugation with monoclonal antibodies to vascular endothelial growth factor. The resultant vector nanoparticles were low-toxic and the antibodies retained their immunochemical activity after conjugation. The study was carried out on rats with intracranial glioma C6 on day 14 after its implantation. The intravenously injected nanoparticles visualized the brain tumor in contrast to nanoparticles conjugated with nonspecific immunoglobulins that did not accumulate in the tumor.",

keywords = "MRI, magnetic nanoparticles, vascular endothelial growth factor",

author = "Abakumov, {M. A.} and Shein, {S. A.} and H. Vishvasrao and Nukolova, {N. V.} and M. Sokol'Ski-Papkov and Sandalova, {T. O.} and Gubskii, {I. L.} and Grinenko, {N. F.} and Kabanov, {A. V.} and Chekhonin, {V. P.}",

note = "Funding Information: The study was supported by Ministry of Health of the USA (grant RR021937) and Government of the Russian Federation (Regulation No. 220 of the Gov- ernment of the Russian Federation, April 09, 2010, Contract 11G34.31.0004).",

year = "2012",

month = dec,

doi = "10.1007/s10517-012-1929-8",

language = "English (US)",

volume = "154",

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AU - Abakumov, M. A.

AU - Shein, S. A.

AU - Vishvasrao, H.

AU - Nukolova, N. V.

AU - Sokol'Ski-Papkov, M.

AU - Sandalova, T. O.

AU - Gubskii, I. L.

AU - Grinenko, N. F.

AU - Kabanov, A. V.

AU - Chekhonin, V. P.

N1 - Funding Information: The study was supported by Ministry of Health of the USA (grant RR021937) and Government of the Russian Federation (Regulation No. 220 of the Gov- ernment of the Russian Federation, April 09, 2010, Contract 11G34.31.0004).

PY - 2012/12

Y1 - 2012/12

N2 - We developed a method for obtaining iron oxide nanoparticles and their conjugation with monoclonal antibodies to vascular endothelial growth factor. The resultant vector nanoparticles were low-toxic and the antibodies retained their immunochemical activity after conjugation. The study was carried out on rats with intracranial glioma C6 on day 14 after its implantation. The intravenously injected nanoparticles visualized the brain tumor in contrast to nanoparticles conjugated with nonspecific immunoglobulins that did not accumulate in the tumor.

AB - We developed a method for obtaining iron oxide nanoparticles and their conjugation with monoclonal antibodies to vascular endothelial growth factor. The resultant vector nanoparticles were low-toxic and the antibodies retained their immunochemical activity after conjugation. The study was carried out on rats with intracranial glioma C6 on day 14 after its implantation. The intravenously injected nanoparticles visualized the brain tumor in contrast to nanoparticles conjugated with nonspecific immunoglobulins that did not accumulate in the tumor.

KW - MRI

KW - magnetic nanoparticles

KW - vascular endothelial growth factor

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JF - Bulletin of Experimental Biology and Medicine

IS - 2

ER -

Visualization of experimental glioma C6 by MRI with magnetic nanoparticles conjugated with monoclonal antibodies to vascular endothelial growth factor

Abstract

Keywords

ASJC Scopus subject areas

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