Visual Loss after Platelet-rich Plasma Injection into the Face

Emely Z. Karam, Alexander Gan, Rafael Muci Mendoza, Edwing Martinez, Evlyn Perez

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Platelet-rich plasma has become one of the most widely used facial cosmetics fillers. We evaluated four patients treated by cosmetologists with platelet-rich plasma injections who developed irreversible blindness due to iatrogenic occlusion of the ophthalmic artery; immediately after the injection in the glabellar area in three cases and in the nasolabial fold in one case. Early after the injections the fundi of all patients demonstrated central retinal artery and choroidal occlusions. Later, two patients developed retinal pigment dispersion and one of them a pigmented optic disc. The scars on the skin showed similar characteristics in all patients, which could constitute an important marker in the presumptive diagnosis of platelet-rich plasma injection associated complications.

Original languageEnglish (US)
Pages (from-to)371-378
Number of pages8
Issue number6
StatePublished - 2020
Externally publishedYes


  • Platelet-rich plasma
  • blindness
  • ophthalmic artery occlusion
  • optic nerve pigmentation

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology


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