Virulent Treponema pallidum: aerobe or anaerobe

J. B. Baseman, J. C. Nichols, N. S. Hayes

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Substrate degradation and protein synthesis served as indicators of metabolism in virulent Treponema pallidum. Optimal metabolic activity in these spirochetes was observed at 10 to 20% O2 concentrations, with markedly reduced activity at higher or lower O2 levels or under anaerobiosis; alternate functioning electron acceptors that might substitute for O2 were not found. Carbon monoxide and cyanide at concentrations that inactivate cytochrome oxidase were not effective metabolic poisons for T. pallidum, although Micrococcus lutea, a strict aerobe with cytochrome dependent respiration, was inhibited under similar experimental conditions. Motility of virulent T. pallidum was vigorous in the presence of O2 and sluggish or inhibited in its absence, reinforcing the role of O2 in T. pallidum metabolism.

Original languageEnglish (US)
Pages (from-to)704-711
Number of pages8
JournalInfection and Immunity
Volume13
Issue number3
StatePublished - 1976
Externally publishedYes

Fingerprint

Treponema pallidum
Anaerobiosis
Micrococcus
Spirochaetales
Poisons
Cyanides
Electron Transport Complex IV
Carbon Monoxide
Cytochromes
Proteolysis
Respiration
Electrons

ASJC Scopus subject areas

  • Immunology

Cite this

Baseman, J. B., Nichols, J. C., & Hayes, N. S. (1976). Virulent Treponema pallidum: aerobe or anaerobe. Infection and Immunity, 13(3), 704-711.

Virulent Treponema pallidum : aerobe or anaerobe. / Baseman, J. B.; Nichols, J. C.; Hayes, N. S.

In: Infection and Immunity, Vol. 13, No. 3, 1976, p. 704-711.

Research output: Contribution to journalArticle

Baseman, JB, Nichols, JC & Hayes, NS 1976, 'Virulent Treponema pallidum: aerobe or anaerobe', Infection and Immunity, vol. 13, no. 3, pp. 704-711.
Baseman JB, Nichols JC, Hayes NS. Virulent Treponema pallidum: aerobe or anaerobe. Infection and Immunity. 1976;13(3):704-711.
Baseman, J. B. ; Nichols, J. C. ; Hayes, N. S. / Virulent Treponema pallidum : aerobe or anaerobe. In: Infection and Immunity. 1976 ; Vol. 13, No. 3. pp. 704-711.
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