Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans

Andreas Sandgren, Barbara Albiger, Carlos J. Orihuela, Elaine Tuomanen, Staffan Normark, Birgitta Henriques-Normark

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Streptococcus pneumoniae isolates of serotypes 1, 4, 6B, 7F, 14, and 19F belonging to clonal types with known invasive disease potential in humans were used to infect C57BL/6 and BALB/c mice. Most isolates were able to colonize the nasopharynx for 7 days. One serotype 19F isolate of the clonal type ST162 had higher bacterial numbers than other isolates and clonal types of the same serotype. Serotype 4 clones caused the most-severe invasive disease, whereas serotype 1 clones caused low-level bacteremia without disease symptoms. BALB/c mice were more likely than C57BL/6 mice to develop meningitis. Disease kinetics varied significantly between clonal types. Although most induced a robust tumor necrosis factor response, some isolates of serotype 1 and 7F did not, suggesting that invasive disease caused by different clonal types may result in different degrees of host response. Capsular serotype, other clonal properties, and host factors are important for the development of pneumococcal disease.

Original languageEnglish (US)
Pages (from-to)791-800
Number of pages10
JournalJournal of Infectious Diseases
Volume192
Issue number5
DOIs
StatePublished - Sep 1 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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