Very high dose loxapine in refractory schizophrenic patients

C. R. Lehman, L. Ereshefsky, S. R. Saklad, T. E. Mings

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations


    The authors report on three chronic, treatment refractory schizophrenic patients who dramatically improved when placed on very high doses of loxapine (300-500 mg/day). Numbness transiently appeared in two patients at very high doses of loxapine; it may be a frequently occurring but unreported side effect. The relative lack of serious side effects to very high dose loxapine suggests that this may be a useful intervention in carefully selected refractory patients. The authors recommended that controlled studies be done to elucidate the benefit to risk ratio.

    Original languageEnglish (US)
    Pages (from-to)1212-1214
    Number of pages3
    JournalAmerican Journal of Psychiatry
    Issue number9
    StatePublished - Jan 1 1981

    ASJC Scopus subject areas

    • Psychiatry and Mental health


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