Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia

William P. Horan, David L. Braff, Keith H. Nuechterlein, Catherine A. Sugar, Kristin S. Cadenhead, Monica E. Calkins, Dorcas J. Dobie, Robert Freedman, Tiffany A. Greenwood, Raquel E. Gur, Ruben C. Gur, Gregory A. Light, Jim Mintz, Ann Olincy, Allan D. Radant, Nicholas J. Schork, Larry J. Seidman, Larry J. Siever, Jeremy M. Silverman, William S. StoneNeal R. Swerdlow, Debbie W. Tsuang, Ming T. Tsuang, Bruce I. Turetsky, Michael F. Green

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Working memory (WM) impairment is a promising candidate endophenotype for schizophrenia that could facilitate the identification of susceptibility genes for this disorder. The validity of this putative endophenotype was assessed by determining whether 149 probands with schizophrenia and 337 of their first-degree relatives demonstrated WM impairment as compared to 190 unaffected community comparison subjects. Subjects were participants in the Consortium on the Genetics of Schizophrenia (COGS) project, a seven-site research network that was established to investigate the genetic architecture of endophenotypes for schizophrenia. Participants received comprehensive clinical assessments and completed two verbal WM tasks, one requiring transient on-line storage and another requiring maintenance plus complex manipulation of information by reordering the stimuli. Schizophrenia probands performed worse than the other groups on both tasks, with larger deficits found for the more challenging reordering WM task. The probands' relatives performed more poorly than community comparison subjects on both tasks, but the difference was significant only for the more challenging maintenance plus complex manipulation WM task. This WM impairment was not attributable to diagnoses of schizophrenia spectrum disorder, mood disorders, or substance use disorders in the relatives. In conjunction with evidence that WM abilities are substantially heritable, the current results support the validity and usefulness of verbal WM impairments in manipulation of information as endophenotypes for schizophrenia in large-scale genetic linkage and association studies.

Original languageEnglish (US)
Pages (from-to)218-228
Number of pages11
JournalSchizophrenia Research
Volume103
Issue number1-3
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Short-Term Memory
Schizophrenia
Endophenotypes
Maintenance
Genetic Linkage
Aptitude
Genetic Association Studies
Mood Disorders
Reproducibility of Results
Substance-Related Disorders
Research
Genes

Keywords

  • Endophenotype
  • Genetics
  • Schizophrenia
  • Working memory

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives : Findings from the Consortium on the Genetics of Schizophrenia. / Horan, William P.; Braff, David L.; Nuechterlein, Keith H.; Sugar, Catherine A.; Cadenhead, Kristin S.; Calkins, Monica E.; Dobie, Dorcas J.; Freedman, Robert; Greenwood, Tiffany A.; Gur, Raquel E.; Gur, Ruben C.; Light, Gregory A.; Mintz, Jim; Olincy, Ann; Radant, Allan D.; Schork, Nicholas J.; Seidman, Larry J.; Siever, Larry J.; Silverman, Jeremy M.; Stone, William S.; Swerdlow, Neal R.; Tsuang, Debbie W.; Tsuang, Ming T.; Turetsky, Bruce I.; Green, Michael F.

In: Schizophrenia Research, Vol. 103, No. 1-3, 08.2008, p. 218-228.

Research output: Contribution to journalArticle

Horan, WP, Braff, DL, Nuechterlein, KH, Sugar, CA, Cadenhead, KS, Calkins, ME, Dobie, DJ, Freedman, R, Greenwood, TA, Gur, RE, Gur, RC, Light, GA, Mintz, J, Olincy, A, Radant, AD, Schork, NJ, Seidman, LJ, Siever, LJ, Silverman, JM, Stone, WS, Swerdlow, NR, Tsuang, DW, Tsuang, MT, Turetsky, BI & Green, MF 2008, 'Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia', Schizophrenia Research, vol. 103, no. 1-3, pp. 218-228. https://doi.org/10.1016/j.schres.2008.02.014
Horan, William P. ; Braff, David L. ; Nuechterlein, Keith H. ; Sugar, Catherine A. ; Cadenhead, Kristin S. ; Calkins, Monica E. ; Dobie, Dorcas J. ; Freedman, Robert ; Greenwood, Tiffany A. ; Gur, Raquel E. ; Gur, Ruben C. ; Light, Gregory A. ; Mintz, Jim ; Olincy, Ann ; Radant, Allan D. ; Schork, Nicholas J. ; Seidman, Larry J. ; Siever, Larry J. ; Silverman, Jeremy M. ; Stone, William S. ; Swerdlow, Neal R. ; Tsuang, Debbie W. ; Tsuang, Ming T. ; Turetsky, Bruce I. ; Green, Michael F. / Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives : Findings from the Consortium on the Genetics of Schizophrenia. In: Schizophrenia Research. 2008 ; Vol. 103, No. 1-3. pp. 218-228.
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