A 41-year-old male with cardiomyopathy from an inherited β myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.
- Hypertrophic cardiomyopathy
- Intramyocardial cell therapy
- Stem cells
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Cardiology and Cardiovascular Medicine