Ventilation-perfusion alterations after smoke inhalation injury in an ovine model

Takeshi Shimazu, Tetsuo Yukioka, Hisashi Ikeuchi, Arthur D. Mason, Peter D. Wagner, Basil A. Pruitt

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


To study the pathophysiological mechanism of progressive hypoxemia after smoke inhalation injury, alterations in ventilation-perfusion ratio (V̇A/Q̇) were studied in an ovine model by using the multiple inert gas elimination technique. Because ethane was detected in expired gas of some sheep, we replaced ethane with krypton, which was a unique application of the multiple inert gas elimination technique when one of the experimental gases is present in the inspirate. Severity-related changes were studied 24 h after injury in control and mild, moderate, and severe inhalathin injury groups. Time-related changes were studied in controls and sheep with moderate injury at 6, 12, 24, and 72 h. Arterial PO2 decreased progressively with severity of injury as well as with time. In smoke-exposed animals, blood flow was recruited to low V̇A/Q̇ compartment (0 < V̇A/Q̇ < 0.1; 17.6 ± 10.6% of cardiac output, 24 h, moderate injury) from normal V̇A/Q̇ compartment (0.1 < V̇A/Q̇ < 10). However, increases in true shunt (V̇A/Q̇ = 0; 5.6 ± 2.5%, 24 h, moderate injury) and dead space were not consistent findings. The V̇A/Q̇ patterns suggest the primary change in smoke inhalation injury to be a disturbance of ventilation.

Original languageEnglish (US)
Pages (from-to)2250-2259
Number of pages10
JournalJournal of applied physiology
Issue number5
StatePublished - Nov 1996


  • gas chromatography-mass spectrometry
  • krypton
  • low ventilation-perfusion
  • lung injury
  • severity-related changes
  • time-related changes

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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