Vasopressors and Inotropes in Sepsis

Leeanne Stratton, David A. Berlin, John E. Arbo

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Vasopressor and inotropes are beneficial in shock states. Norepinephrine is considered the first-line vasopressor for patients with sepsis-associated hypotension. Dobutamine is considered the first-line inotrope in sepsis, and should be considered for patients with evidence of myocardial dysfunction or ongoing signs of hypoperfusion. Vasopressor and inotrope therapy has complex effects that are often difficult to predict; emergency providers should consider the physiology and clinical trial data. It is essential to continually reevaluate the patient to determine if the selected treatment is having the intended result.

Original languageEnglish (US)
Pages (from-to)75-91
Number of pages17
JournalEmergency Medicine Clinics of North America
Issue number1
StatePublished - Feb 1 2017
Externally publishedYes


  • Cardiac contractility
  • Dopamine
  • Epinephrine
  • Inotropes
  • Norepinephrine
  • Sepsis
  • Septic shock
  • Vasopressors

ASJC Scopus subject areas

  • Emergency Medicine


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