Vasopressin in the rat with partial nephrectomy-salt hypertension

W. J. Lee-Kwon, L. Share, J. T. Crofton, R. E. Shade, B. Brooks, E. E. Muirhead, M. Manning, W. H. Sawyer

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    24 Scopus citations

    Abstract

    The role of vasopressin in the pathogenesis of partial ne-phrectomy (PN)-salt hypertension was examined in the rat. Hypertension was produced by reducing renal mass 70% and substituting 1% saline for drinking water 2 to 4 days after surgery. PN alone resulted in an increase in systolic blood pressure. Subsequent salt loading led to a further large increase in arterial pressure. On the second to third day after substitution of saline for drinking water, urinary vasopressin excretion (UADHV) was increased six-fold and the plasma vasopressin concentration was increased two and one-half-fold. UADHV) then fell to a level that was threefold greater than control values 5 days later. Although there was a marked stimulation of vasopressin release during the period of

    Original languageEnglish (US)
    Pages (from-to)281-297
    Number of pages17
    JournalClinical and Experimental Hypertension
    Volume3
    Issue number2
    DOIs
    StatePublished - 1981

    ASJC Scopus subject areas

    • Internal Medicine
    • Physiology

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