Vasopressin in the rat with partial nephrectomy-salt hypertension

W. J. Lee-Kwon; L. Share; J. T. Crofton; R. E. Shade; B. Brooks; E. E. Muirhead; M. Manning; W. H. Sawyer

doi:10.3109/10641968109033665

Vasopressin in the rat with partial nephrectomy-salt hypertension

W. J. Lee-Kwon, L. Share, J. T. Crofton, R. E. Shade, B. Brooks, E. E. Muirhead, M. Manning, W. H. Sawyer

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26 Scopus citations

Abstract

The role of vasopressin in the pathogenesis of partial ne-phrectomy (PN)-salt hypertension was examined in the rat. Hypertension was produced by reducing renal mass 70% and substituting 1% saline for drinking water 2 to 4 days after surgery. PN alone resulted in an increase in systolic blood pressure. Subsequent salt loading led to a further large increase in arterial pressure. On the second to third day after substitution of saline for drinking water, urinary vasopressin excretion (U_ADHV) was increased six-fold and the plasma vasopressin concentration was increased two and one-half-fold. U_ADHV) then fell to a level that was threefold greater than control values 5 days later. Although there was a marked stimulation of vasopressin release during the period of

Original language	English (US)
Pages (from-to)	281-297
Number of pages	17
Journal	Clinical and Experimental Hypertension
Volume	3
Issue number	2
DOIs	https://doi.org/10.3109/10641968109033665
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine
Physiology

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title = "Vasopressin in the rat with partial nephrectomy-salt hypertension",

abstract = "The role of vasopressin in the pathogenesis of partial ne-phrectomy (PN)-salt hypertension was examined in the rat. Hypertension was produced by reducing renal mass 70% and substituting 1% saline for drinking water 2 to 4 days after surgery. PN alone resulted in an increase in systolic blood pressure. Subsequent salt loading led to a further large increase in arterial pressure. On the second to third day after substitution of saline for drinking water, urinary vasopressin excretion (UADHV) was increased six-fold and the plasma vasopressin concentration was increased two and one-half-fold. UADHV) then fell to a level that was threefold greater than control values 5 days later. Although there was a marked stimulation of vasopressin release during the period of",

author = "Lee-Kwon, {W. J.} and L. Share and Crofton, {J. T.} and Shade, {R. E.} and B. Brooks and Muirhead, {E. E.} and M. Manning and Sawyer, {W. H.}",

note = "Funding Information: This work was supported by USPHS grants HL-19209 and HL-12990 from the National Heart, Lung and Blood Institute of the National Institutes of Health. The authors are grateful to Cynthia Allen, Linda K. Long, and Deborah Tarnowski for their dedicated and expert technical assistance.",

year = "1981",

doi = "10.3109/10641968109033665",

language = "English (US)",

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journal = "Clinical and Experimental Hypertension",

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T1 - Vasopressin in the rat with partial nephrectomy-salt hypertension

AU - Lee-Kwon, W. J.

AU - Share, L.

AU - Crofton, J. T.

AU - Shade, R. E.

AU - Brooks, B.

AU - Muirhead, E. E.

AU - Manning, M.

AU - Sawyer, W. H.

N1 - Funding Information: This work was supported by USPHS grants HL-19209 and HL-12990 from the National Heart, Lung and Blood Institute of the National Institutes of Health. The authors are grateful to Cynthia Allen, Linda K. Long, and Deborah Tarnowski for their dedicated and expert technical assistance.

PY - 1981

Y1 - 1981

N2 - The role of vasopressin in the pathogenesis of partial ne-phrectomy (PN)-salt hypertension was examined in the rat. Hypertension was produced by reducing renal mass 70% and substituting 1% saline for drinking water 2 to 4 days after surgery. PN alone resulted in an increase in systolic blood pressure. Subsequent salt loading led to a further large increase in arterial pressure. On the second to third day after substitution of saline for drinking water, urinary vasopressin excretion (UADHV) was increased six-fold and the plasma vasopressin concentration was increased two and one-half-fold. UADHV) then fell to a level that was threefold greater than control values 5 days later. Although there was a marked stimulation of vasopressin release during the period of

AB - The role of vasopressin in the pathogenesis of partial ne-phrectomy (PN)-salt hypertension was examined in the rat. Hypertension was produced by reducing renal mass 70% and substituting 1% saline for drinking water 2 to 4 days after surgery. PN alone resulted in an increase in systolic blood pressure. Subsequent salt loading led to a further large increase in arterial pressure. On the second to third day after substitution of saline for drinking water, urinary vasopressin excretion (UADHV) was increased six-fold and the plasma vasopressin concentration was increased two and one-half-fold. UADHV) then fell to a level that was threefold greater than control values 5 days later. Although there was a marked stimulation of vasopressin release during the period of

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Vasopressin in the rat with partial nephrectomy-salt hypertension

Abstract

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