Vascular niche contribution to age-associated neural stem cell dysfunction

Deana M. Apple, Erzsebet Kokovay

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Neural stem cells (NSCs) persist throughout life in the dentate gyrus and the ventricularsubventricular zone, where they continuously provide new neurons and some glia. These cells are found in specialized niches that regulate quiescence, activation, differentiation, and cell fate choice. A key aspect of the regulatory niche is the vascular plexus, which modulates NSC behavior during tissue homeostasis and regeneration. During aging, NSCs become depleted and dysfunctional, resulting in reduced neurogenesis and poor brain repair. In this review, we discuss the emerging evidence that changes in the vascular niche both structurally and functionally contribute to reduced neurogenesis during aging and how this might contribute to reduced plasticity and repair in the aged brain.

Original languageEnglish (US)
Pages (from-to)H896-H902
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume313
Issue number5
DOIs
StatePublished - Nov 2017

Keywords

  • Aging
  • Neural stem cell
  • Neurogenesis
  • Niche
  • Vasculature

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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