Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease

Veronica Galvan, Matthew J. Hart

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Aging is the strongest known risk factor for Alzheimer's disease (AD). With the discovery of the mechanistic target of rapamycin (mTOR) as a critical pathway controlling the rate of aging in mice, molecules at the interface between the regulation of aging and the mechanisms of specific age-associated diseases can be identified. We will review emerging evidence that mTOR-dependent brain vascular dysfunction, a universal feature of aging, may be one of the mechanisms linking the regulation of the rate of aging to the pathogenesis of Alzheimer's disease. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

Original languageEnglish (US)
Pages (from-to)992-1007
Number of pages16
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1862
Issue number5
DOIs
StatePublished - May 1 2016

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Keywords

  • Aging
  • Alzheimer's
  • Geroscience
  • MTOR
  • Neurovascular aging
  • Target of rapamycin

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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