Vascular metallomics: Copper in the vasculature

Renee N. Easter, Qilin Chan, Barry Lai, Erik L. Ritman, Joseph A. Caruso, Zhenyu Qin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Owing to recent progress in analytical techniques, metallomics are evolving from detecting distinct trace metals in a defined state to monitor the dynamic changes in the abundance and location of trace metals in vitro and in vivo. Vascular metallomics is an emerging field that studies the role of trace metals in vasculature. This review will introduce common metallomics techniques including atomic absorption spectrometry, inductively coupled plasma-atomic emission spectrometry, inductively coupled plasma-mass spectrometry and X-ray fluorescence spectrometry with a summary table to compare these techniques. Moreover, we will summarize recent research findings that have applied these techniques to human population studies in cardiovascular diseases, with a particular emphasis on the role of copper in these diseases. In order to address the issue of interdisciplinary studies between metallomics and vascular biology, we will review the progress of efforts to understand the role of copper in neovascularization. This recent advance in the metallomics field may be a powerful tool to elucidate the signaling pathways and specific biological functions of these trace metals. Finally, we summarize the evidence to support the notion that copper is a dynamic signaling molecule. As a future direction, vascular metallomics studies may lead to the identification of targets for diagnosis and therapy in cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalVascular Medicine
Volume15
Issue number1
DOIs
StatePublished - Feb 2010
Externally publishedYes

Fingerprint

Blood Vessels
Copper
Metals
Spectrum Analysis
Cardiovascular Diseases
Interdisciplinary Studies
X-Ray Emission Spectrometry
Mass Spectrometry
Research
Population
Therapeutics

Keywords

  • Vascular diseases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Easter, R. N., Chan, Q., Lai, B., Ritman, E. L., Caruso, J. A., & Qin, Z. (2010). Vascular metallomics: Copper in the vasculature. Vascular Medicine, 15(1), 61-69. https://doi.org/10.1177/1358863X09346656

Vascular metallomics : Copper in the vasculature. / Easter, Renee N.; Chan, Qilin; Lai, Barry; Ritman, Erik L.; Caruso, Joseph A.; Qin, Zhenyu.

In: Vascular Medicine, Vol. 15, No. 1, 02.2010, p. 61-69.

Research output: Contribution to journalArticle

Easter, RN, Chan, Q, Lai, B, Ritman, EL, Caruso, JA & Qin, Z 2010, 'Vascular metallomics: Copper in the vasculature', Vascular Medicine, vol. 15, no. 1, pp. 61-69. https://doi.org/10.1177/1358863X09346656
Easter RN, Chan Q, Lai B, Ritman EL, Caruso JA, Qin Z. Vascular metallomics: Copper in the vasculature. Vascular Medicine. 2010 Feb;15(1):61-69. https://doi.org/10.1177/1358863X09346656
Easter, Renee N. ; Chan, Qilin ; Lai, Barry ; Ritman, Erik L. ; Caruso, Joseph A. ; Qin, Zhenyu. / Vascular metallomics : Copper in the vasculature. In: Vascular Medicine. 2010 ; Vol. 15, No. 1. pp. 61-69.
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