Vascular Inflammation in Mouse Models of Systemic Lupus Erythematosus

Holly Ryan, Laurence Morel, Erika Moore

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Vascular inflammation mediated by overly activated immune cells is a significant cause of morbidity and mortality in systemic lupus erythematosus (SLE). Several mouse models to study the pathogenesis of SLE are currently in use, many of which have different mechanisms of pathogenesis. The diversity of these models allows interrogation of different aspects of the disease pathogenesis. To better determine the mechanisms by which vascular inflammation occurs in SLE, and to assist future researchers in choosing the most appropriate mouse models to study cardiovascular complications in SLE, we suggest that direct comparisons of vascular inflammation should be conducted among different murine SLE models. We also propose the use of in vitro vascular assays to further investigate vascular inflammation processes prevalent among different murine SLE models.

Original languageEnglish (US)
Article number767450
JournalFrontiers in Cardiovascular Medicine
Volume9
DOIs
StatePublished - Mar 28 2022
Externally publishedYes

Keywords

  • autoimmune disease
  • cardiovascular diseases
  • in vitro disease modeling
  • mouse models
  • systemic lupus erythematosus
  • vascular inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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