Vascular function, cerebral cortical thickness, and cognitive performance in middle-aged hispanic and non-hispanic caucasian adults

Evan P. Pasha, Sonya S. Kaur, Mitzi M. Gonzales, Daniel R. Machin, Kennon Kasischke, Hirofumi Tanaka, Andreana P. Haley

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Hispanics are at increased risk for acquiring cardiovascular risk factors that contribute to cognitive dysfunction. To compare indices of vascular health with measures of cerebral gray matter integrity, 60 middle-aged Hispanic and non-Hispanic Caucasian participants were matched across age, sex, years of education, and mental status. Arterial stiffness was characterized by β-stiffness index and carotid-femoral pulse wave velocity, and magnetic resonance imaging estimated cortical thickness in a priori regions of interest known to be susceptible to vascular risk factors. Measures of arterial stiffness were significantly higher in Hispanics than in non-Hispanic Caucasians. Hispanics exhibited thinner left inferior frontal gyrus (LIFG) cortical thickness (P = 04) with concurrently lower language (P = 02), memory (P = 03), and attention-executive functioning (P = 02). These results suggest that compromised vascular health may occur simultaneously with cortical thinning of the LIFG as an early neuropathological alteration in Hispanics.

Original languageEnglish (US)
Pages (from-to)306-312
Number of pages7
JournalJournal of Clinical Hypertension
Volume17
Issue number4
DOIs
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Vascular function, cerebral cortical thickness, and cognitive performance in middle-aged hispanic and non-hispanic caucasian adults'. Together they form a unique fingerprint.

Cite this