TY - JOUR
T1 - Vascular contributions to cognitive impairment and dementia (VCID)
T2 - A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop
AU - Zlokovic, Berislav V.
AU - Gottesman, Rebecca F.
AU - Bernstein, Kenneth E.
AU - Seshadri, Sudha
AU - McKee, Ann
AU - Snyder, Heather
AU - Greenberg, Steven M.
AU - Yaffe, Kristine
AU - Schaffer, Chris B.
AU - Yuan, Chun
AU - Hughes, Timothy M.
AU - Daemen, Mat J.
AU - Williamson, Jeff D.
AU - González, Hector M.
AU - Schneider, Julie
AU - Wellington, Cheryl L.
AU - Katusic, Zvonimir S.
AU - Stoeckel, Luke
AU - Koenig, James I.
AU - Corriveau, Roderick A.
AU - Fine, Lawrence
AU - Galis, Zorina S.
AU - Reis, Jared
AU - Wright, Jacqueline D.
AU - Chen, Jue
N1 - Publisher Copyright:
© 2020 the Alzheimer's Association
PY - 2020/12
Y1 - 2020/12
N2 - Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.
AB - Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.
KW - Alzheimer's disease-related dementias
KW - cerebrovascular and cardiovascular disease
KW - vascular contributions to cognitive impairment and dementia
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U2 - 10.1002/alz.12157
DO - 10.1002/alz.12157
M3 - Review article
C2 - 33030307
AN - SCOPUS:85092405421
SN - 1552-5260
VL - 16
SP - 1714
EP - 1733
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 12
ER -