Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop

Berislav V. Zlokovic, Rebecca F. Gottesman, Kenneth E. Bernstein, Sudha Seshadri, Ann McKee, Heather Snyder, Steven M. Greenberg, Kristine Yaffe, Chris B. Schaffer, Chun Yuan, Timothy M. Hughes, Mat J. Daemen, Jeff D. Williamson, Hector M. González, Julie Schneider, Cheryl L. Wellington, Zvonimir S. Katusic, Luke Stoeckel, James I. Koenig, Roderick A. CorriveauLawrence Fine, Zorina S. Galis, Jared Reis, Jacqueline D. Wright, Jue Chen

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.

Original languageEnglish (US)
Pages (from-to)1714-1733
Number of pages20
JournalAlzheimer's and Dementia
Volume16
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • Alzheimer's disease-related dementias
  • cerebrovascular and cardiovascular disease
  • vascular contributions to cognitive impairment and dementia

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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