Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine

Myron J. Levin, M. N. Oxman, J. H. Zhang, G. R. Johnson, H. Stanley, A. R. Hayward, M. J. Caulfield, M. R. Irwin, J. G. Smith, J. Clair, I. S F Chan, H. Williams, R. Harbecke, R. Marchese, S. E. Straus, A. Gershon, A. Weinberg, Michael N. Oxman, Robert Arbeit, Patricia Barry & 50 others Chris Beisel, Kathy D. Boardman, Cindy L. Colling, Larry Davis, Lawrence Gelb, Anne A. Gershon, Anthony R. Hayward, Michael R. Irwin, Gary R. Johnson, Peter N. Peduzzi, Kenneth Schmader, Michael S. Simberkoff, Stephen E. Straus, Adriana Weinberg, Heather M. Williams, Jeffrey L. Silber, Paula Annunziato, Christina Y. Chan, Ivan S F Chan, L. E. Davis, C. A. Kauffman, S. K. Keay, A. R. Marques, N. E. Soto, P. Brunell, J. W. Gnann, R. Serrao, D. J. Cotton, R. P. Goodman, R. D. Arbeit, C. T. Pachucki, M. J. Levin, K. E. Schmader, W. A. Keitel, R. N. Greenberg, V. A. Morrison, P. F. Wright, M. R. Griffin, M. S. Simberkoff, S. S. Yeh, Z. Lobo, M. Holodniy, J. Loutit, R. F. Betts, L. D. Gelb, George E Crawford, J. Guatelli, P. A. Brooks, K. M. Neuzil, J. F. Toney

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

Background. A double-blind, placebo-controlled trial that involved 38,546 subjects ≥60 years old demonstrated efficacy of a high-potency live-attenuated Oka/Merck varicella-zoster virus (VZV) vaccine. The trial included an immunology substudy to determine the relationship of VZV-specific immune responses to vaccination and clinical outcome. Methods. The immunology substudy enrolled 1395 subjects at 2 sites where blood samples obtained prior to vaccination, at 6 weeks after vaccination, and at 1, 2, and 3 years thereafter were tested for VZV-specific cell-mediated immunity (VZV-CMI) by γ-interferon ELISPOT and responder cell frequency assays and for VZV antibody by glycoprotein ELISA. Results. VZV-CMI and VZV antibodies were significantly increased in vaccine recipients at 6 weeks after vaccination. The vaccine-induced increases in VZV-CMI persisted during the 3 years of follow-up, although their magnitude decreased over time. The magnitude of these VZV-specific immune responses was greater in subjects 60-69 years old than in subjects ≥70 years old. Conclusions. The zoster vaccine induced a significant increase in VZV-CMI and VZV antibody. The magnitude and duration of the boost in VZV-CMI in vaccine recipients and the relationship of this boost to age paralleled the clinical effects of the vaccine observed during the efficacy trial. These findings support the hypothesis that boosting VZV-CMI protects older adults against herpes zoster and postherpetic neuralgia.

Original languageEnglish (US)
Pages (from-to)825-835
Number of pages11
JournalJournal of Infectious Diseases
Volume197
Issue number6
DOIs
StatePublished - Mar 15 2008
Externally publishedYes

Fingerprint

Herpes Zoster Vaccine
Human Herpesvirus 3
Vaccination
Vaccines
Allergy and Immunology
Antibodies
Postherpetic Neuralgia
Enzyme-Linked Immunospot Assay
Herpes Zoster
Cellular Immunity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Levin, M. J., Oxman, M. N., Zhang, J. H., Johnson, G. R., Stanley, H., Hayward, A. R., ... Toney, J. F. (2008). Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine. Journal of Infectious Diseases, 197(6), 825-835. https://doi.org/10.1086/528696

Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine. / Levin, Myron J.; Oxman, M. N.; Zhang, J. H.; Johnson, G. R.; Stanley, H.; Hayward, A. R.; Caulfield, M. J.; Irwin, M. R.; Smith, J. G.; Clair, J.; Chan, I. S F; Williams, H.; Harbecke, R.; Marchese, R.; Straus, S. E.; Gershon, A.; Weinberg, A.; Oxman, Michael N.; Arbeit, Robert; Barry, Patricia; Beisel, Chris; Boardman, Kathy D.; Colling, Cindy L.; Davis, Larry; Gelb, Lawrence; Gershon, Anne A.; Hayward, Anthony R.; Irwin, Michael R.; Johnson, Gary R.; Peduzzi, Peter N.; Schmader, Kenneth; Simberkoff, Michael S.; Straus, Stephen E.; Weinberg, Adriana; Williams, Heather M.; Silber, Jeffrey L.; Annunziato, Paula; Chan, Christina Y.; Chan, Ivan S F; Davis, L. E.; Kauffman, C. A.; Keay, S. K.; Marques, A. R.; Soto, N. E.; Brunell, P.; Gnann, J. W.; Serrao, R.; Cotton, D. J.; Goodman, R. P.; Arbeit, R. D.; Pachucki, C. T.; Levin, M. J.; Schmader, K. E.; Keitel, W. A.; Greenberg, R. N.; Morrison, V. A.; Wright, P. F.; Griffin, M. R.; Simberkoff, M. S.; Yeh, S. S.; Lobo, Z.; Holodniy, M.; Loutit, J.; Betts, R. F.; Gelb, L. D.; Crawford, George E; Guatelli, J.; Brooks, P. A.; Neuzil, K. M.; Toney, J. F.

In: Journal of Infectious Diseases, Vol. 197, No. 6, 15.03.2008, p. 825-835.

Research output: Contribution to journalArticle

Levin, MJ, Oxman, MN, Zhang, JH, Johnson, GR, Stanley, H, Hayward, AR, Caulfield, MJ, Irwin, MR, Smith, JG, Clair, J, Chan, ISF, Williams, H, Harbecke, R, Marchese, R, Straus, SE, Gershon, A, Weinberg, A, Oxman, MN, Arbeit, R, Barry, P, Beisel, C, Boardman, KD, Colling, CL, Davis, L, Gelb, L, Gershon, AA, Hayward, AR, Irwin, MR, Johnson, GR, Peduzzi, PN, Schmader, K, Simberkoff, MS, Straus, SE, Weinberg, A, Williams, HM, Silber, JL, Annunziato, P, Chan, CY, Chan, ISF, Davis, LE, Kauffman, CA, Keay, SK, Marques, AR, Soto, NE, Brunell, P, Gnann, JW, Serrao, R, Cotton, DJ, Goodman, RP, Arbeit, RD, Pachucki, CT, Levin, MJ, Schmader, KE, Keitel, WA, Greenberg, RN, Morrison, VA, Wright, PF, Griffin, MR, Simberkoff, MS, Yeh, SS, Lobo, Z, Holodniy, M, Loutit, J, Betts, RF, Gelb, LD, Crawford, GE, Guatelli, J, Brooks, PA, Neuzil, KM & Toney, JF 2008, 'Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine', Journal of Infectious Diseases, vol. 197, no. 6, pp. 825-835. https://doi.org/10.1086/528696
Levin, Myron J. ; Oxman, M. N. ; Zhang, J. H. ; Johnson, G. R. ; Stanley, H. ; Hayward, A. R. ; Caulfield, M. J. ; Irwin, M. R. ; Smith, J. G. ; Clair, J. ; Chan, I. S F ; Williams, H. ; Harbecke, R. ; Marchese, R. ; Straus, S. E. ; Gershon, A. ; Weinberg, A. ; Oxman, Michael N. ; Arbeit, Robert ; Barry, Patricia ; Beisel, Chris ; Boardman, Kathy D. ; Colling, Cindy L. ; Davis, Larry ; Gelb, Lawrence ; Gershon, Anne A. ; Hayward, Anthony R. ; Irwin, Michael R. ; Johnson, Gary R. ; Peduzzi, Peter N. ; Schmader, Kenneth ; Simberkoff, Michael S. ; Straus, Stephen E. ; Weinberg, Adriana ; Williams, Heather M. ; Silber, Jeffrey L. ; Annunziato, Paula ; Chan, Christina Y. ; Chan, Ivan S F ; Davis, L. E. ; Kauffman, C. A. ; Keay, S. K. ; Marques, A. R. ; Soto, N. E. ; Brunell, P. ; Gnann, J. W. ; Serrao, R. ; Cotton, D. J. ; Goodman, R. P. ; Arbeit, R. D. ; Pachucki, C. T. ; Levin, M. J. ; Schmader, K. E. ; Keitel, W. A. ; Greenberg, R. N. ; Morrison, V. A. ; Wright, P. F. ; Griffin, M. R. ; Simberkoff, M. S. ; Yeh, S. S. ; Lobo, Z. ; Holodniy, M. ; Loutit, J. ; Betts, R. F. ; Gelb, L. D. ; Crawford, George E ; Guatelli, J. ; Brooks, P. A. ; Neuzil, K. M. ; Toney, J. F. / Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine. In: Journal of Infectious Diseases. 2008 ; Vol. 197, No. 6. pp. 825-835.
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title = "Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine",
abstract = "Background. A double-blind, placebo-controlled trial that involved 38,546 subjects ≥60 years old demonstrated efficacy of a high-potency live-attenuated Oka/Merck varicella-zoster virus (VZV) vaccine. The trial included an immunology substudy to determine the relationship of VZV-specific immune responses to vaccination and clinical outcome. Methods. The immunology substudy enrolled 1395 subjects at 2 sites where blood samples obtained prior to vaccination, at 6 weeks after vaccination, and at 1, 2, and 3 years thereafter were tested for VZV-specific cell-mediated immunity (VZV-CMI) by γ-interferon ELISPOT and responder cell frequency assays and for VZV antibody by glycoprotein ELISA. Results. VZV-CMI and VZV antibodies were significantly increased in vaccine recipients at 6 weeks after vaccination. The vaccine-induced increases in VZV-CMI persisted during the 3 years of follow-up, although their magnitude decreased over time. The magnitude of these VZV-specific immune responses was greater in subjects 60-69 years old than in subjects ≥70 years old. Conclusions. The zoster vaccine induced a significant increase in VZV-CMI and VZV antibody. The magnitude and duration of the boost in VZV-CMI in vaccine recipients and the relationship of this boost to age paralleled the clinical effects of the vaccine observed during the efficacy trial. These findings support the hypothesis that boosting VZV-CMI protects older adults against herpes zoster and postherpetic neuralgia.",
author = "Levin, {Myron J.} and Oxman, {M. N.} and Zhang, {J. H.} and Johnson, {G. R.} and H. Stanley and Hayward, {A. R.} and Caulfield, {M. J.} and Irwin, {M. R.} and Smith, {J. G.} and J. Clair and Chan, {I. S F} and H. Williams and R. Harbecke and R. Marchese and Straus, {S. E.} and A. Gershon and A. Weinberg and Oxman, {Michael N.} and Robert Arbeit and Patricia Barry and Chris Beisel and Boardman, {Kathy D.} and Colling, {Cindy L.} and Larry Davis and Lawrence Gelb and Gershon, {Anne A.} and Hayward, {Anthony R.} and Irwin, {Michael R.} and Johnson, {Gary R.} and Peduzzi, {Peter N.} and Kenneth Schmader and Simberkoff, {Michael S.} and Straus, {Stephen E.} and Adriana Weinberg and Williams, {Heather M.} and Silber, {Jeffrey L.} and Paula Annunziato and Chan, {Christina Y.} and Chan, {Ivan S F} and Davis, {L. E.} and Kauffman, {C. A.} and Keay, {S. K.} and Marques, {A. R.} and Soto, {N. E.} and P. Brunell and Gnann, {J. W.} and R. Serrao and Cotton, {D. J.} and Goodman, {R. P.} and Arbeit, {R. D.} and Pachucki, {C. T.} and Levin, {M. J.} and Schmader, {K. E.} and Keitel, {W. A.} and Greenberg, {R. N.} and Morrison, {V. A.} and Wright, {P. F.} and Griffin, {M. R.} and Simberkoff, {M. S.} and Yeh, {S. S.} and Z. Lobo and M. Holodniy and J. Loutit and Betts, {R. F.} and Gelb, {L. D.} and Crawford, {George E} and J. Guatelli and Brooks, {P. A.} and Neuzil, {K. M.} and Toney, {J. F.}",
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TY - JOUR

T1 - Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine

AU - Levin, Myron J.

AU - Oxman, M. N.

AU - Zhang, J. H.

AU - Johnson, G. R.

AU - Stanley, H.

AU - Hayward, A. R.

AU - Caulfield, M. J.

AU - Irwin, M. R.

AU - Smith, J. G.

AU - Clair, J.

AU - Chan, I. S F

AU - Williams, H.

AU - Harbecke, R.

AU - Marchese, R.

AU - Straus, S. E.

AU - Gershon, A.

AU - Weinberg, A.

AU - Oxman, Michael N.

AU - Arbeit, Robert

AU - Barry, Patricia

AU - Beisel, Chris

AU - Boardman, Kathy D.

AU - Colling, Cindy L.

AU - Davis, Larry

AU - Gelb, Lawrence

AU - Gershon, Anne A.

AU - Hayward, Anthony R.

AU - Irwin, Michael R.

AU - Johnson, Gary R.

AU - Peduzzi, Peter N.

AU - Schmader, Kenneth

AU - Simberkoff, Michael S.

AU - Straus, Stephen E.

AU - Weinberg, Adriana

AU - Williams, Heather M.

AU - Silber, Jeffrey L.

AU - Annunziato, Paula

AU - Chan, Christina Y.

AU - Chan, Ivan S F

AU - Davis, L. E.

AU - Kauffman, C. A.

AU - Keay, S. K.

AU - Marques, A. R.

AU - Soto, N. E.

AU - Brunell, P.

AU - Gnann, J. W.

AU - Serrao, R.

AU - Cotton, D. J.

AU - Goodman, R. P.

AU - Arbeit, R. D.

AU - Pachucki, C. T.

AU - Levin, M. J.

AU - Schmader, K. E.

AU - Keitel, W. A.

AU - Greenberg, R. N.

AU - Morrison, V. A.

AU - Wright, P. F.

AU - Griffin, M. R.

AU - Simberkoff, M. S.

AU - Yeh, S. S.

AU - Lobo, Z.

AU - Holodniy, M.

AU - Loutit, J.

AU - Betts, R. F.

AU - Gelb, L. D.

AU - Crawford, George E

AU - Guatelli, J.

AU - Brooks, P. A.

AU - Neuzil, K. M.

AU - Toney, J. F.

PY - 2008/3/15

Y1 - 2008/3/15

N2 - Background. A double-blind, placebo-controlled trial that involved 38,546 subjects ≥60 years old demonstrated efficacy of a high-potency live-attenuated Oka/Merck varicella-zoster virus (VZV) vaccine. The trial included an immunology substudy to determine the relationship of VZV-specific immune responses to vaccination and clinical outcome. Methods. The immunology substudy enrolled 1395 subjects at 2 sites where blood samples obtained prior to vaccination, at 6 weeks after vaccination, and at 1, 2, and 3 years thereafter were tested for VZV-specific cell-mediated immunity (VZV-CMI) by γ-interferon ELISPOT and responder cell frequency assays and for VZV antibody by glycoprotein ELISA. Results. VZV-CMI and VZV antibodies were significantly increased in vaccine recipients at 6 weeks after vaccination. The vaccine-induced increases in VZV-CMI persisted during the 3 years of follow-up, although their magnitude decreased over time. The magnitude of these VZV-specific immune responses was greater in subjects 60-69 years old than in subjects ≥70 years old. Conclusions. The zoster vaccine induced a significant increase in VZV-CMI and VZV antibody. The magnitude and duration of the boost in VZV-CMI in vaccine recipients and the relationship of this boost to age paralleled the clinical effects of the vaccine observed during the efficacy trial. These findings support the hypothesis that boosting VZV-CMI protects older adults against herpes zoster and postherpetic neuralgia.

AB - Background. A double-blind, placebo-controlled trial that involved 38,546 subjects ≥60 years old demonstrated efficacy of a high-potency live-attenuated Oka/Merck varicella-zoster virus (VZV) vaccine. The trial included an immunology substudy to determine the relationship of VZV-specific immune responses to vaccination and clinical outcome. Methods. The immunology substudy enrolled 1395 subjects at 2 sites where blood samples obtained prior to vaccination, at 6 weeks after vaccination, and at 1, 2, and 3 years thereafter were tested for VZV-specific cell-mediated immunity (VZV-CMI) by γ-interferon ELISPOT and responder cell frequency assays and for VZV antibody by glycoprotein ELISA. Results. VZV-CMI and VZV antibodies were significantly increased in vaccine recipients at 6 weeks after vaccination. The vaccine-induced increases in VZV-CMI persisted during the 3 years of follow-up, although their magnitude decreased over time. The magnitude of these VZV-specific immune responses was greater in subjects 60-69 years old than in subjects ≥70 years old. Conclusions. The zoster vaccine induced a significant increase in VZV-CMI and VZV antibody. The magnitude and duration of the boost in VZV-CMI in vaccine recipients and the relationship of this boost to age paralleled the clinical effects of the vaccine observed during the efficacy trial. These findings support the hypothesis that boosting VZV-CMI protects older adults against herpes zoster and postherpetic neuralgia.

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DO - 10.1086/528696

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SP - 825

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