Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry

Emelia J. Benjamin, Kenneth M. Rice, Dan E. Arking, Arne Pfeufer, Charlotte Van Noord, Albert V. Smith, Renate B. Schnabel, Joshua C. Bis, Eric Boerwinkle, Moritz F. Sinner, Abbas Dehghan, Steven A. Lubitz, Ralph B. D'Agostino, Thomas Lumley, Georg B. Ehret, Jan Heeringa, Thor Aspelund, Christopher Newton-Cheh, Martin G. Larson, Kristin D. MarcianteElsayed Z. Soliman, Fernando Rivadeneira, Thomas J. Wang, Gudny Eiríksdottir, Daniel Levy, Bruce M. Psaty, Man Li, Alanna M. Chamberlain, Albert Hofman, Ramachandran S. Vasan, Tamara B. Harris, Jerome I. Rotter, W. H.Linda Kao, Sunil K. Agarwal, Bruno H.Ch Stricker, Ke Wang, Lenore J. Launer, Nicholas L. Smith, Aravinda Chakravarti, André G. Uitterlinden, Philip A. Wolf, Nona Sotoodehnia, Anna Köttgen, Cornelia M. Van Duijn, Thomas Meitinger, Martina Mueller, Siegfried Perz, Gerhard Steinbeck, H. Erich Wichmann, Kathryn L. Lunetta, Susan R. Heckbert, Vilmundur Gudnason, Alvaro Alonso, Stefan Kääb, Patrick T. Ellinor, Jacqueline C.M. Witteman

Research output: Contribution to journalArticlepeer-review

327 Scopus citations


We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10 -11; combined RR = 1.25; combined P = 1.8 × 10 -15).

Original languageEnglish (US)
Pages (from-to)879-881
Number of pages3
JournalNature Genetics
Issue number8
StatePublished - Aug 2009
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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