Variability of hydroxy-itraconazole in relation to itraconazole bloodstream concentrations

Nathan P. Wiederhold, Ilan S. Schwartz, Thomas F Patterson, George R. Thompson

Research output: Contribution to journalArticlepeer-review

Abstract

We analyzed the relationship between itraconazole (ITZ) and hydroxyitraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson’s r, 0.7838), and OH-ITZ levels were generally higher than ITZ levels (median OH-ITZ:ITZ ratio, 1.73; range, 0.13 to 8.96). However, marked variability was observed throughout the range of ITZ concentrations. Thus, it is difficult to predict OH-ITZ concentrations based solely on ITZ levels.

Original languageEnglish (US)
Article numbere02353-20
JournalAntimicrobial agents and chemotherapy
Volume65
Issue number4
DOIs
StatePublished - Apr 2021

Keywords

  • Antifungal efficacy
  • Bioassay
  • Bloodstream concentrations
  • Hydroxy-itraconazole
  • Itraconazole
  • TDM
  • Therapeutic-drug monitoring

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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